Multimodality management of unilateral wilms' tumor in children : a better guidance by histopathological examination
Joint Authors
Zakariyya, Usamah Muhammad
Farraj, Sharif H.
Adli, Usamah A.
Hassanin, Suhayr Abd al-Muhsin Ihab
Zamzam, Maha L.
Loulah, Majdi A.
Sadiq, Yasir S.
al-Shaykh, Huda
Source
Suez Canal University Medical Journal
Issue
Vol. 8, Issue 1 (31 Mar. 2005), pp.45-52, 8 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2005-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
-Background .'Although wilms' tumor is among the most common primary malignant tumors in childhood, controversy still exists regarding its best mode of treatment.
Aim:This study aimed at comparing the results of two different protocols in treatment of wilms tumor in three different institutes.
Patients and Methods:Twenty four children were included in this study .
Inclusion criteria were ; localized disease , histologically confirmed wilms’ tumor or clinical , ultrasonic and CT characteristics of nephroblastoma .
Children were divided into two equal groups in each institute .In group I (n = 12) preoperative chemotherapy was initiated according to ultrasonic and CT diagnosis , whereas in group II (n = 12) chemotherapy was decided according to surgical staging and biopsy .Radical excision of the tumor was done when amenable; however, in those with residual masses, metal clips were left to identify them in follow up .
Results: In group I, 7 patients were preoperativeiy diagnosed as stage II, while the remaining 5 patients were preoperativeiy diagnosed as being stage 111 .
Postoperatively one patient was found to be stage II instead of being stage III before chemotherapy .
In group II, 9 patients were proved to be stage II, whereas 3 patients were stage III .
The postoperative follow-up was identical for both groups .Yet, in group I, 2 patients with stage II disease (25%), showed CT evidenced recurrences .
Complete remission was noted in 3 out of the 4 stage III patients (75 %) , the remaining one showed poor response to treatment and died with disease .
In group II, one patient with stage II (11.1%) showed C.T evidence of recurrence , salvaged with chemotherapy and radiotherapy .
Also, one patient with stage III showed relapse (33.3%), and respond moderately to second chemotherapy and still living with disease .
Conclusion: We have recommended that stage I and II, disease is better managed according to NWTSG recommendations , whereas preoperative chemotherapy is reserved to higher stages III, IV and bilateral disease .
Key Words : Wilms tumour, Children, Chemotherapy and Surgery
American Psychological Association (APA)
Zakariyya, Usamah Muhammad& Farraj, Sharif H.& Adli, Usamah A.& Hassanin, Suhayr Abd al-Muhsin Ihab& Zamzam, Maha L.& Loulah, Majdi A.…[et al.]. 2005. Multimodality management of unilateral wilms' tumor in children : a better guidance by histopathological examination. Suez Canal University Medical Journal،Vol. 8, no. 1, pp.45-52.
https://search.emarefa.net/detail/BIM-370183
Modern Language Association (MLA)
Zakariyya, Usamah Muhammad…[et al.]. Multimodality management of unilateral wilms' tumor in children : a better guidance by histopathological examination. Suez Canal University Medical Journal Vol. 8, no. 1 (Mar. 2005), pp.45-52.
https://search.emarefa.net/detail/BIM-370183
American Medical Association (AMA)
Zakariyya, Usamah Muhammad& Farraj, Sharif H.& Adli, Usamah A.& Hassanin, Suhayr Abd al-Muhsin Ihab& Zamzam, Maha L.& Loulah, Majdi A.…[et al.]. Multimodality management of unilateral wilms' tumor in children : a better guidance by histopathological examination. Suez Canal University Medical Journal. 2005. Vol. 8, no. 1, pp.45-52.
https://search.emarefa.net/detail/BIM-370183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 51-52
Record ID
BIM-370183