The use of diazepam on reducing ketamine hemodynamic side effects (heart rate blood pressure)‎ during induction period of anaestheia

Abstract EN

The study was designed to see the effect of diazepam 0.2 mg / kg I.V.

before the usual induction dose of ketamine 2 mg / kg I.V.

on the cardiovascular parameters (heart rate, diastolic and systolic blood pressures).

Eighty patients were scheduled for elective surgery allocated in two groups : [group A : (n = 40) received ketamine 2mg.kg IV and cardiovascular parameters were measured], and [group B : (n = 40) diazepam 0.2 mg / kg I.V.

preceded ketamine by 5 minutes and cardiovascular parameters were measured].

Group A showed a significant increase in (heart rate and blood pressure) on test period.

In group B: there is a significant decrease in (heart and blood pressure).

The study support the idea that diazepam is effective in reducing cardiovascular effects of ketamine to make smooth induction of anaesthesia.