Antifungal and antibacterial activity of flavonoid extract from Terminalia chebula Retz. fruits

Abstract EN

The present study was designed to determine the antifungal, antibacterial and cytotoxicity activities of the flavonoid extracted from Terminalia chebula Retz.

fruits.

The flavonoid extract showed greater antifungal activity against Aspergillus funigalus than Candida albicans by using agar well diffusion method for all concentrations, It was found that these activities increased with the extract concentration increases .The Diameter of the inhibition zone of Aspergillus funigalus (30 mm) while Candida albicans (21 mm) at a concentration of is (150 mg / ml).

The results showed that the antibacterial activity of flavonoid extract against gram positive (Staphylococcus aureus, and Streptococcus spp.) bacteria greater than gram negative (Klebsiella pneumonia, Pseudomonas aeruginosa and, E.

coli).

The extract showed high activity against Streptococcus spp.

with inhibition zone (36 mm) than that of (Klebsiella pneumonia, Pseudomonas aeruginosa and, E.

coli) (30 mm) at a concentration of 500 mg / ml, and minimum inhibitory concentration of flavonoid extract was ( 25 mg / ml ) for Staphylococcus aureus and ( 100 mg / ml ) for E.

coli .The results of cytotoxicity against the human red blood cells proved that the flavonoid extractR R had no cytotoxic effect at all the concentrations tested (ranging between 0.5-250 ppm), by using DMSO solution as a control.