Biological activity of 4-(2-methoxy benzylidene amino)‎ phenyl mercuric chloride and 4-(2-chlorobenzylidene amino)‎ phenyl mercuric chloride compounds

Abstract EN

The 4-(2-methoxy benzylidene amino) phenyl mercuric chloride and 4-(2-chlorobenzylidene amino) phenyl mercuric chloride were investigated for their biological activity against standard strains of Staphylococcus aureus ATCC 25923 and Ecsherichia coli ATCC 25922.

The results showed that there is a potent antibacterial activity of these compounds.

Minimal inhibitory concentration was determined for these two compounds, it was 4 µg/ml, 5 µg / ml for Staph.

aureus, and 15 µg / ml, 20 µg / ml for E.

coli respectively.

Cytotoxicity assay was carried out against human red blood corpuscles, the two compounds exhibited a toxic effect in high concentrations on RBCs while in high diluted concentrations have no toxic effect on it.