Histopathological and biochemical study of thallium sulfate toxicity on kidneys of white laboratory rats (Rattus Norvegicus)
Other Title(s)
دراسة الامراضيه النسيجية و الكيموحيويه للتسمم بكبريتات الثاليوم على الكلى في الجرذان ألمختبريه البيضاء (Rattus norvegicus)
Joint Authors
Majid, Salih Kazim
Khudayr, Zaynab Wahid
Chayan, Mazin Adil
Source
Basrah Journal of Veterinary Research
Issue
Vol. 13, Issue 1 (30 Jun. 2014), pp.211-221, 11 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2014-06-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract AR
في هذه التجربة تم استخدام 48 جرذ مختبر حيث قسمت هذه الحيوانات إلى أربع مجاميع احتوت كل مجموعة على 12 حيوان (6 ذكور و 6 إناث).
كل هذه الحيوانات جرعت فمويا محلول مائي لكبريتات الثاليوم و كالأتي : 4,0.
0,8.
1,6 ملغ/ كغم وزن الجسم بالترتيب بينما مجموعة السيطرة تم إعطاؤها ماء الملح الفسيولوجي.
استمرت هذه التجربة 90 يوما، بعد نهاية هذه الفترة تم تخدير كل الحيوانات بالكلوروفورم عن طريق الاستنشاق و قتلها للحصول على مصل الدم لغرض حساب تركيز اليوريا و الكرياتنين فيه و كذلك لدراسة الأمراضية النسيجسة التي حدثت بسبب التسمم بسلفات الثاليوم على النسيج الكلي.
بالمقارنة مع مجموعة السيطرة
Abstract EN
In this study 48 rats were used and divided into four groups : A, B, C and D each group contains 12 rats.
All these groups were administrated orally with aqueous solution of thallium sulfate as 0.4 mg / kg b.
w., 0.8 mg / kg b.
w., 1.6 mg / kg b.
w.
respectively while the control group(A) was administrated with normal saline.
This experiment was continued for 90 days.
After this period all animals were anesthetized with chloroform by inhalation and sacrificed to collect blood samples for obtaining the serum which used for estimation of serum urea and creatinine, and to study histopathological changes caused by thallium sulfate toxicity on kidney tissue.
Compared with control group, all treated groups showed markedly dose–dependent elevation in serum urea and creatinine, and pathological changes as dilatation and vacoulation of cortical tubules and atrophy of glomeruli and also necrosis of proximal convoluted tubules in high dose group.
American Psychological Association (APA)
Chayan, Mazin Adil& Khudayr, Zaynab Wahid& Majid, Salih Kazim. 2014. Histopathological and biochemical study of thallium sulfate toxicity on kidneys of white laboratory rats (Rattus Norvegicus). Basrah Journal of Veterinary Research،Vol. 13, no. 1, pp.211-221.
https://search.emarefa.net/detail/BIM-372813
Modern Language Association (MLA)
Majid, Salih Kazim…[et al.]. Histopathological and biochemical study of thallium sulfate toxicity on kidneys of white laboratory rats (Rattus Norvegicus). Basrah Journal of Veterinary Research Vol. 13, no. 1 (2014), pp.211-221.
https://search.emarefa.net/detail/BIM-372813
American Medical Association (AMA)
Chayan, Mazin Adil& Khudayr, Zaynab Wahid& Majid, Salih Kazim. Histopathological and biochemical study of thallium sulfate toxicity on kidneys of white laboratory rats (Rattus Norvegicus). Basrah Journal of Veterinary Research. 2014. Vol. 13, no. 1, pp.211-221.
https://search.emarefa.net/detail/BIM-372813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 219-221
Record ID
BIM-372813