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Comparative evaluation of the effect of Nigella sativa extracts and nystatin as a traditional drug on Candida albicans in the primary school students in Mosul and Tikrit cities
Joint Authors
Yahya, Maymunah K.
al-Tai, Abd al-Rahman A.
Source
Issue
Vol. 13, Issue 2 (31 Dec. 2013), pp.70-78, 9 p.
Publisher
University of Mosul College of Pharmacy
Publication Date
2013-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract AR
373274 أهداف البحث : صممت الدراسة للكشف عن التأثير التثبيطي لمستخلصات الحبة السوداء و مقارنتها الشائعة الاستعمال ضد الفطر .Candida albicans المقدمة : إن التطور الحاصل في مقاومة الأحياء المجهرية و لما موجود من مضادات حيوية أصبح مشكلة خطيرة، حيث تستعمل بذور الحبة السوداء في الطب الشعبي منذ فترة طويلة لعلاج الالتهابات المختلفة لذا فأن تصنيع مثل هكذا مواد حاجة حقيقية خصوصا في المستشفيات و المراكز الصحية. المواد و طريقة العمل : استعملنا عدة تراكيز من مستخلصات الحبة السوداء المائي و الكحولي (40، 35، 30، 25، 20، 15، 10) ملغم \ مل ضد الفطر Candida albicans المعزول من تلاميذ المدارس الابتدائية المصابين.
و قد تم دراسة تأثيره و مقارنتها مع النيستاتين باستعمال الانتشار بالأقراص. النتائج : بينت النتائج أن المستخلص المائي ليس له تأثير تثبيطي، أما المستخلص الكحولي لحبة السوداء المستعمل بمختلف التراكيز لغاية تركيز 40 ملغم \ مل. الاستنتاج : أثبتت الدراسة أن الحبة السوداء مصدرا للأدوية المضادة للفطريات و كذلك في الطب البديل لعلاج الالتهابات المعوية الفطرية.
Abstract EN
Objectives : To detect and compare the inhibitory effect of Nigella sativa extracts and compare their effects with traditional drugs on Candida albicans.
Introduction : The developing microbial resistance to the existing anti-microbial agents has become a real challenge and a serious problem.
Seeds of Nigella sativa have been used for a long time in folk medicine for the treatment of such infections.
Production of new potent agents is urgently needed, especially for hospitals and health centers.
Therefore, the antifungal effect of aqueous and alcoholic extracts of the seeds against Candida albicans from primary school students were investigated.
Materials and Methods : The in vitro antifungal effect of the extracts at a concentration of (10, 15, 20, 25, 30, 35, 40)mg ⁄ ml on C.
albicans isolated was assessed and compared with traditional drug, nystatin using agar diffusion assay.
Results : The aqueous extract did not show any inhibitory effect against the isolated Candida.
The alcoholic extract indicated significant inhibitory effect.
nystatin show inhibitory effect higher than alcoholic extract at a concentration 40 mg ⁄ ml.
Discussion : The results of this study revealed clear potentiality of N.
sativa as a source for antifungal drugs and support its use in folk medicine for the treatment of fungal intestinal infections.
This finding warrants necessity of further investigation of this product of folk medicine.
American Psychological Association (APA)
Yahya, Maymunah K.& al-Tai, Abd al-Rahman A.. 2013. Comparative evaluation of the effect of Nigella sativa extracts and nystatin as a traditional drug on Candida albicans in the primary school students in Mosul and Tikrit cities. Iraqi Journal of Pharmacy،Vol. 13, no. 2, pp.70-78.
https://search.emarefa.net/detail/BIM-373274
Modern Language Association (MLA)
Yahya, Maymunah K.& al-Tai, Abd al-Rahman A.. Comparative evaluation of the effect of Nigella sativa extracts and nystatin as a traditional drug on Candida albicans in the primary school students in Mosul and Tikrit cities. Iraqi Journal of Pharmacy Vol. 13, no. 2 (2013), pp.70-78.
https://search.emarefa.net/detail/BIM-373274
American Medical Association (AMA)
Yahya, Maymunah K.& al-Tai, Abd al-Rahman A.. Comparative evaluation of the effect of Nigella sativa extracts and nystatin as a traditional drug on Candida albicans in the primary school students in Mosul and Tikrit cities. Iraqi Journal of Pharmacy. 2013. Vol. 13, no. 2, pp.70-78.
https://search.emarefa.net/detail/BIM-373274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 77-78
Record ID
BIM-373274