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Antimicrobial activity of some medicinal plants against strains causing wound infections
Dissertant
Thesis advisor
University
Omdurman Islamic University
Faculty
Faculty of Sciences and Technology
Department
Department of Botany
University Country
Sudan
Degree
Master
Degree Date
2005
English Abstract
The ethanolic, Petroleum ether, ethyl acetate, methanolic and water extracts of some medicinal plants (Acacia nilotica SPSS.
nilotica pods, Lawsonia inermis leaves, Azadirachta indica leaves, Trigonella foenum-greacum seeds and Cordia sinensis stem bark) were investigated for their antimicrobial activity against six standard bacterial strains commonly associated with wound infections ( Staphylococcus aureus (ATCC 25923), Bacillus subtilis (NCTC 8236), Escherichia coli (ATCC 25922), Proteus vulgaris (ATCC 6380), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 1312) and three locally isolated strains (Staphylococcus aureus, Proteus vulgaris and Pseudomonas aeruginosa) and also against two standard fungal strains (Candida albicans ( ATCC7596) and Aspergillus niger (ATCC 9763)) in vitro. Plant extracts at a concentration of 100 mg/ml were applied using the agar plate well-diffusion method. All the extractives obtained from Acacia nilotica ssp nilotica pods were showed a range of activity against all tested standard bacterial strains.
In particular, the ethyl acetate and methanol extracts showed the highest levels of activity.
Among the tested extract of Lawsonia inermis, the methanol and ethanol extracts of the leaf showed the more potent antibacterial activity.
The leaf water extract of Azadirachta indica showed the highest levels of activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
These results may provide a justification to some traditional uses of these plants.
The least antibacterially active plants were Trigonella foenum-graecum and Cordia sinensis. Most susceptible Gram-negative standard bacterium was Klebsiella pneumoniae and least susceptible Gram-negative bacterium was Escherichia coli.
In Gram-positive standard bacteria, most susceptible bacterium was Staphylococcus aureus. Compared to reference antibiotics (Tetracycline, Ampicillin), some plant extracts exhibited broader spectrum of antibacterial activity and were found to be clearly superior in case of extracts of Acacia nilotica ssp.
nilotica and Lawsonia inermis against Klebsiella pneumoniae. The ethanol extract of Acacia nilotica ssp.
nilotica showed the more potent antifungal activity.
Main Subjects
No. of Pages
125
Table of Contents
Table of contents.
Abstract.
Chpter One : Introduction.
Chapter Two : Literature Review.
Chapter Three : Materials and methods.
Chapter Four : Results and discussion.
Discussion, conculsion, recommendations.
References.
American Psychological Association (APA)
al-Karim, Ihsan Musa Awad. (2005). Antimicrobial activity of some medicinal plants against strains causing wound infections. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-373282
Modern Language Association (MLA)
al-Karim, Ihsan Musa Awad. Antimicrobial activity of some medicinal plants against strains causing wound infections. (Master's theses Theses and Dissertations Master). Omdurman Islamic University. (2005).
https://search.emarefa.net/detail/BIM-373282
American Medical Association (AMA)
al-Karim, Ihsan Musa Awad. (2005). Antimicrobial activity of some medicinal plants against strains causing wound infections. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-373282
Language
English
Data Type
Arab Theses
Record ID
BIM-373282