Risk factors for pre mature ovarian failure in women from Babylon Iraq

Abstract EN

Background : Premature ovarian failure (POF) is a common cause of infertility in women characterized by amenorrhea, hypoestrogenism and elevated gonadotrophin level in women under the age of 40.

The ethnic prevalence variations pose possible etiologic differences also due to environmental, genetic, and nutritional factors.

Conduction of etiologic studies in different settings or populations can help in improving the knowledge regarding etiology and predictors of POF. Objective : To determine possible risk factors of POF in subset of women from Babylon/Iraq. Patients and Methods : This study includesFifty- three Selected womenfrom Al- Amalclinic for infertility management and treatment in Babylon, patients were categorized in three groups, A : those women are the premature ovarian failure group, (comprise 26 patients, n = 26, age <40years (mean 30.23 years) follicular stimulating hormone (FSH) > 14 mIu \ ml).

Group B : twelve women who reached natural menopause (n = 12,age ≥40 years(mean 42.75 years) FSH> 20 mIu / ml, Group C : Fifteen known normally cycling fertile women mean age 27.06 years, FSH 7.05 mIu / ml (n = 15).

All studied groups were asked about their maternal age of natural menopause, body mass index (BMI) were calculated and asked about menstrual cycle pattern and if previous fertility is present or not.

Blood group type was stated for all women.

All inhabitants registered with an address in Babylon \ Iraq.

Results : There was no significant difference in maternal age of menopause between groups, neither in BMI.

Blood group type O ranked higher significant percentage in group A women than other two groups, while other blood types show no significant difference.

Sixty-five percent of group a women presented with infertility and irregular menstruation was reported in 80.8 % of participants in the same group, which is significantly different from group B and C. Conclusion : Maternal age of menopause constitute no risk factor for POF in our study population this may be due to the fact that they have underwent extensive psychological and environmental pollution in the last 20 years that have detrimental effect on ovarian reserve of the female, or may be due to small sample size.

Blood group O seems to be a risk factor as well as the presence of previous infertility and menstrual irregularities.