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HLA typing in Iraqi patients with obesity and primary osteoarthritis
Joint Authors
Abd al-Karim, Faris
al-Mukhtar, Sadiq Abbas
Zalzalah, Haydar Hashim
Mahdi, Batul Mutar
Rauf, Hiyam
Abid, Lahib Ali
Nihad, Zaynah
Source
al-Kindy College Medical Journal
Issue
Vol. 9, Issue 2 (31 Dec. 2013), pp.49-52, 4 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2013-12-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Topics
Abstract EN
Osteoarthritis (OA) is a degenerative joint disease.
It is one of the major causes of disability in developed and developing countries.
Human leukocyte antigen (HLA) as part of immune system has a role in the disease process.
Objjecttiives:: To investigate whether there is an association between HLA class II-DRB and OA.
Metthods:: A case control study with 26 patients with osteoarthritis and 22 apparently healthy obese control persons matching in ethnicity were enrolled in this study during the period between October 2012 till March 2013.
Direct interview was done with each patient and HLA typing was done by molecular method using Sequence Specific Primer (PCR-SSP) method using One Lambda Kit-USA.
Resulltts:: The results showed that females were more affected than males with disease when compared with control.
Odds ratio were used to test level of significance.
This study showed that HLA DR4 (DRB1*04), DR2 (DRB1*15 and DRB1*16), DR9 (DRB1*09), DR10 (DRB1*10, DRB5*, DRB4* and DRB3*) (odds ratio: 14.26, 9, 9, 9, 14.26, 9.5 and 4.5) respectively are associated with OA.
Concllusiions:: OA is highly associated with HLA class II DR4 (DRB1*04), DR2 (DRB1*15, DRB1*16), DR9 (DRB1*09), and DR10 (DRB1*10).DR5 (DRB1*05) is not associated with OA.
American Psychological Association (APA)
al-Mukhtar, Sadiq Abbas& Abd al-Karim, Faris& Zalzalah, Haydar Hashim& Mahdi, Batul Mutar& Rauf, Hiyam& Abid, Lahib Ali…[et al.]. 2013. HLA typing in Iraqi patients with obesity and primary osteoarthritis. al-Kindy College Medical Journal،Vol. 9, no. 2, pp.49-52.
https://search.emarefa.net/detail/BIM-374340
Modern Language Association (MLA)
al-Mukhtar, Sadiq Abbas…[et al.]. HLA typing in Iraqi patients with obesity and primary osteoarthritis. al-Kindy College Medical Journal Vol. 9, no. 2 (2013), pp.49-52.
https://search.emarefa.net/detail/BIM-374340
American Medical Association (AMA)
al-Mukhtar, Sadiq Abbas& Abd al-Karim, Faris& Zalzalah, Haydar Hashim& Mahdi, Batul Mutar& Rauf, Hiyam& Abid, Lahib Ali…[et al.]. HLA typing in Iraqi patients with obesity and primary osteoarthritis. al-Kindy College Medical Journal. 2013. Vol. 9, no. 2, pp.49-52.
https://search.emarefa.net/detail/BIM-374340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 51-52
Record ID
BIM-374340