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Study of plasma amino acid levels in children with autism : an Egyptian sample
Joint Authors
al-Baz, Faridah M.
al-Durri, Ghadah Faraj
Zaki, Muna M.
Yusuf, Azzah M.
al-Alfi, Dina Y.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 15, Issue 2 (30 Apr. 2014), pp.181-186, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : The aetiology of autism is unclear and autistic symptoms had been attributed to an abnormal functional imbalance in neurotransmitter amines such as dopamine, noradrenaline and serotonin.
Objective : To study plasma essential and non-essential amino acid levels, protein electrophoresis, serum ammonia, and urea in autistic children in comparison with controls.
Methods : Twenty autistic children were compared to twenty healthy age and sex matched normal children serving as control, where serum amino acids, urea, ammonia and protein electrophoresis were estimated.
Results : As regards essential amino acid levels, autistic children had significant lower plasma levels of leucine, isoleucine, phenylalanine, methionine and cystine than controls (P < 0.05),while there was no statistical difference in the level of tryptophan, valine, threonine, arginine, lysine and histidine (P > 0.05).
In non-essential amino acid levels, phosphoserine was significantly raised in autistic children than in controls (P < 0.05).
Autistic children had lower level of hydroxyproline, serine and tyrosine than controls (P < 0.05).
On the other hand there was no significant difference in levels of taurin, asparagine, alanine, citrulline, GABA, glycine, glutamic acid, and ornithine (P > 0.05).
There was no significant difference between cases and controls as regards the levels of urea, ammonia, total proteins, albumin and globulins (alpha 1, alpha 2, beta and gamma) (P > 0.05).
American Psychological Association (APA)
al-Baz, Faridah M.& Zaki, Muna M.& Yusuf, Azzah M.& al-Durri, Ghadah Faraj& al-Alfi, Dina Y.. 2014. Study of plasma amino acid levels in children with autism : an Egyptian sample. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 2, pp.181-186.
https://search.emarefa.net/detail/BIM-374477
Modern Language Association (MLA)
al-Baz, Faridah M.…[et al.]. Study of plasma amino acid levels in children with autism : an Egyptian sample. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 2 (Apr. 2014), pp.181-186.
https://search.emarefa.net/detail/BIM-374477
American Medical Association (AMA)
al-Baz, Faridah M.& Zaki, Muna M.& Yusuf, Azzah M.& al-Durri, Ghadah Faraj& al-Alfi, Dina Y.. Study of plasma amino acid levels in children with autism : an Egyptian sample. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 2, pp.181-186.
https://search.emarefa.net/detail/BIM-374477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 185-186
Record ID
BIM-374477