The promoter region (G-800A and C-509T) polymorphisms of transforming growth factor-β1 gene among young women with recurrent urinary tract infection
Joint Authors
Harapan, Harapan
Syukri, Maimun
Sjabani, Mochammad
Soesatyo, Marsetyawan Hne
Astuti, Indwiani
Umran, Umran
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 15, Issue 2 (30 Apr. 2014), pp.125-130, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Recurrent urinary tract infection (UTI) is common among young women and one of its risk factors is genetic.
Polymorphisms in promoter region (G-800A (rs1800468) and C-509T (rs1800469)) of transforming growth factor-b1 (TGF-b1) gene play pivotal roles in several infection diseases but the association of these polymorphisms with recurrent UTI remains unclear.
The aim of this study was to assess the correlation of TGF-b1 G-800A and C-509T polymorphisms with recurrent UTI in young women.
Subjects and methods : TGF-b1 G-800A and C-509T polymorphisms among 34 recurrent UTI patients and 34 healthy subjects, aged 15–50 years old, were evaluated with polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) and confirmed by DNA sequencing.
Results : At position 800, genotypes showed no significant differences between recurrent UTI patients (GG 97.1 % ; GA 2.9 % ; AA 0 %) and normal control (GG 97 % ; GA 0 % ; AA 2.9 %) young.
American Psychological Association (APA)
Syukri, Maimun& Sjabani, Mochammad& Soesatyo, Marsetyawan Hne& Astuti, Indwiani& Umran, Umran& Harapan, Harapan. 2014. The promoter region (G-800A and C-509T) polymorphisms of transforming growth factor-β1 gene among young women with recurrent urinary tract infection. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 2, pp.125-130.
https://search.emarefa.net/detail/BIM-374492
Modern Language Association (MLA)
Syukri, Maimun…[et al.]. The promoter region (G-800A and C-509T) polymorphisms of transforming growth factor-β1 gene among young women with recurrent urinary tract infection. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 2 (Apr. 2014), pp.125-130.
https://search.emarefa.net/detail/BIM-374492
American Medical Association (AMA)
Syukri, Maimun& Sjabani, Mochammad& Soesatyo, Marsetyawan Hne& Astuti, Indwiani& Umran, Umran& Harapan, Harapan. The promoter region (G-800A and C-509T) polymorphisms of transforming growth factor-β1 gene among young women with recurrent urinary tract infection. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 2, pp.125-130.
https://search.emarefa.net/detail/BIM-374492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 129-130
Record ID
BIM-374492