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Telomerase activity detection in cholesteatoma
Joint Authors
al-Anwar, Muhammad Wahid
Jawdah, Majdi Ibrahim
Husni, Samih Muhammad
Ali, Maha Atfi
Source
Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Issue
Vol. 14, Issue 1 (31 Mar. 2013), pp.7-10, 4 p.
Publisher
Egyptian Society of Ear Nose Throat and Allied Science
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : In cholesteatoma, there is lack of control over cell proliferation that is why ectodermal tissue grows to be an epidermoid cyst.
So cholesteatoma may be considered as cell growth disorder but still the cause of this uncontrolled proliferation is unknown.
Objective : The aim of this study is to detect telomerase activity in cholesteatoma and meatal skin (as a control) and its relation to the clinical findings and severity of the disease.
Patients and methods : Samples of cholesteatoma and meatal skin were obtained from 31 patients during ear surgery.
Telomerase activity was detected using polymerase chain reaction based on telomeric repeat amplification protocol assay then collected data were statistically analyzed.
Results : Telomerase activity was positive in 17 / 31 (54.8 %) of cholesteatoma samples and was negative in all meatal skin samples.
Significant high rates of intraoperative ossicular erosion and preoperative air bone gap more than 40 dB were associated with positive telomerase activity.
Conclusions : Telomerase activity may play a role in the hyperproliferative nature and uncontrolled aggressive growth pattern of cholesteatoma.
ª 2012 Egyptian.
American Psychological Association (APA)
Jawdah, Majdi Ibrahim& al-Anwar, Muhammad Wahid& Husni, Samih Muhammad& Ali, Maha Atfi. 2013. Telomerase activity detection in cholesteatoma. Egyptian Journal of Ear, Nose, Throat and Allied Sciences،Vol. 14, no. 1, pp.7-10.
https://search.emarefa.net/detail/BIM-374965
Modern Language Association (MLA)
Jawdah, Majdi Ibrahim…[et al.]. Telomerase activity detection in cholesteatoma. Egyptian Journal of Ear, Nose, Throat and Allied Sciences Vol. 14, no. 1 (Mar. 2013), pp.7-10.
https://search.emarefa.net/detail/BIM-374965
American Medical Association (AMA)
Jawdah, Majdi Ibrahim& al-Anwar, Muhammad Wahid& Husni, Samih Muhammad& Ali, Maha Atfi. Telomerase activity detection in cholesteatoma. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2013. Vol. 14, no. 1, pp.7-10.
https://search.emarefa.net/detail/BIM-374965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10
Record ID
BIM-374965