Concurrent radiochemotherapy versus surgery followed by radiotherapy for hypopharyngeal carcinoma : a single-center study

Abstract EN

-Hypopharyngeal cancer is a rare disease representing about 0.5% of all human malignancies and constituting only 3–5% of all head and neck cancer.

Concurrent radiochemotherapy has been recommended as a standard of care in patients with locally advanced squamous cell head and neck carcinomas.

There were very few reports about these tumors arising from North Africa.

Objecttive: This work was a retrospective study at the Ain Shams University hospitals comparing induction chemotherapy and concomitant radiochemotherapy to surgery followed by radiotherapy as regards over all survival.

Methods: This study included 49 patients with hypopharyngeal carcinoma, twenty-three (46.93%) were treated surgically.

Surgical excision of the tumor was by pharyngo-laryngo-esophagectomy, except for 2 patients treated by conservative surgery.

Postoperative radiotherapy was given to all patients.

Twenty sex patients (53.07%) were treated by induction chemotherapy and concomitant radiochemotherapy.

Results: The mean age was 52.6 years (range 25–82).

In the present study, females (55.1%) dominated males (44.9%).The most commonly involved subsite, in this study, was the postcricoid area (31 patients = 63.3%), followed by the pyriform sinus (16 patients = 32.6%), while the posterior pharyngael wall was the site of origin in only two patients (4.1%).

According to the AJCC-