Amlodipine and oral health

Abstract EN

To evaluate the oral side effect of amlodipine in patients with cardiovascular disease, also to study the effect of improving oral health on the possibility of development of gingival over growth.

Materials and Methods : The study was conducted on 25 patients (pretreated group) with cardiovascular disease who had been prescribed amlodipine for the first time, aged ranged between 30-63 years.

Clinical examinations (plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD) and gingival over growth scores) were conducted under standardized illumination with plain dental mirror and a periodontal probe.

The screening was done twice, the 1st assessment was collected at base line (pretreatment) visit before the first dose of the amlodipine and they received non surgical periodontal therapy (scaling, root planning and home care instruction) to get them to base line, but the 2nd assessment was done at the end of trial period at 12 week assessments (post treated).

Results : The result obtained showed that the mean values of PI and BOP in post group were significantly lower than pre group (p < 0.05), While for the PPD, GO the mean values in the post group were higher than mean value in the pre group with significant difference for GO (p < 0.05) and no significant difference for PPD (p > 0.05).Conclusion : The study concluded that amlodipine therapy had got its influence on GO and that improvement in oral health represent a scientifically sound complementary intervention in reducing both the occurrence of GO and inflammatory levels in the systemic circulation.