Occurrence of cytomegalovirus and factors causing reactivation of the infection among renal transplants recipients : a single study center
Author
Khaminah, Zakiyah Rustum Zadah
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 19, Issue 1 (28 Feb. 2008), pp.41-46, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2008-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Reactivation of infection with the cytomegalovirus (CMV) in renal transplant recipients may cause significant morbidity and mortality.
To evaluate factors associated with activation of CMV replication, we followed prospectively a group of 68 renal transplant recipients for 12 months.
The control group consisted of healthy blood donors (n = 37).
Sera were collected periodically from these patients and analyzed for the presence of specific anti-CMV antibodies.
Enzyme-linked immunoassay based on recombinant CMV proteins was used to detect the following antibody specificities: IgG and IgM.
During the first year after transplantation, reactivation of CMV occurred in 48 recipients (70.6%).
Detailed analysis did not show any association of reactivation with the type of basic immunosuppressive therapy, prophylactic or therapeutic use of anti-lymphocyte antibodies, as well as occurrence of acute rejection episodes.
There was a borderline association (P=0.068) between the presence of CMV infection and EBV reactivation.
In conclusion, results of our study suggest that CMV infection may represent a factor activating EBV replication.
American Psychological Association (APA)
Khaminah, Zakiyah Rustum Zadah. 2008. Occurrence of cytomegalovirus and factors causing reactivation of the infection among renal transplants recipients : a single study center. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 1, pp.41-46.
https://search.emarefa.net/detail/BIM-37722
Modern Language Association (MLA)
Khaminah, Zakiyah Rustum Zadah. Occurrence of cytomegalovirus and factors causing reactivation of the infection among renal transplants recipients : a single study center. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 1 (Feb. 2008), pp.41-46.
https://search.emarefa.net/detail/BIM-37722
American Medical Association (AMA)
Khaminah, Zakiyah Rustum Zadah. Occurrence of cytomegalovirus and factors causing reactivation of the infection among renal transplants recipients : a single study center. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 1, pp.41-46.
https://search.emarefa.net/detail/BIM-37722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 45-46
Record ID
BIM-37722