The relevance of serum complement C3 with fasting blood glucose levels in obese type 2 diabetics

Abstract EN

The aim of the present study was to verify the relevance of complement, C3 & C4 with fasting blood glucose level (FBGL) in type 2 obese diabetics.

To achieve this aim, 22 obese diabetic patients (12 females & 10 males) with ages of 45.23±13.83 and body mass index (BMI) of 34.52 ± 2.15 Kg.m-² were enrolled.

To compare the results, 20 healthy individuals (10 females & 10 males) of ages 36.55± 5.36 were also included.

Serum C3 and C4 levels were measured in the patients & the control group by a single immune-diffusion method.

Fasting blood glucose level was estimated by the glucoseoxidase method.

In the diabetic patients, serum C3 level was found to be significantly (P < 0.01) elevated when compared with those of healthy individuals whereas C4 didn't show such variation.

The linear regression analysis exhibited a significant positive correlation for C3 (r = 0.45, P< 0.05) with FBGL in diabetics but not in healthy subjects.

Such correlation was also significant (r=0.60, P < 0.001) with the BMI values.

In conclusion, C3 was found to direct the levels of FBGL in type 2 obese diabetic patients.