Prevalence of subclinical hypothyroidism in patients with chronic renal disease in Al-Nassiryah City

Abstract EN

Background : Subclinical hypothyroidism is highly prevalent in the general populations especially in elderly, however, the prevalence of subclinical hypothyroidism in persons with chronic kidney disease is not well studied.

Design : Cross sectional data from (245) persons , 110 persons of them considered as a control group and other persons (135) with chronic kidney disease, all of them were collected from (1-9-2010 to 1-7-2011) in Al– Hussein teaching hospital (out patient and inpatient).

All patients and control group were routinely referred for thyroid function tests, renal function test (in form of plasma creatinine) and estimation of glomerular filtration rate (GFR).

Multivariable logistic study was used to evaluate the independent association between prevalent subclinical hypothyroidism and estimated GFR.

Results : Among (245) adult participants with serum creatinine, GFR and thyroid function test results, the mean age for both groups were (58 ± 4) year, 148 male while 97 of those were female.

The prevelance of subclinical hypothyroidism increased specially with lower GFR (in unit of ml / min.

/ 1.73 m2), occurring in 7.5 % of subject with GFR (60–90 ml /min.) while those patients with GFR less than (60 ml / min.) the prevalence were increased to 16.5 % (P < 0.001 ).

The control group were 110 persons, only 3 participant with subclinincal hypothyroidism (2 %).

A significant difference when we compared patient with chronic kidney disease and control group (P < 0.001).