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Effect of vitamin c on intraocular pressure : an experimental study in rabbits
Author
Source
Issue
Vol. 13, Issue 2 (31 Dec. 2010), pp.263-268, 6 p.
Publisher
University of Kufa Faculty of Medicine
Publication Date
2010-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract AR
عشرون أرنبا (نوع الأبيض النيوزلندي) استخدمت في هذه الدراسة ثم رفع ضغط العين اليمنى للأرانب و بعد ذلك قسمت الأرانب عشوائيا إلى أربع مجاميع (5 كل مجموعة) ثم عولجت الحيوانات بالماء المقطر (المجموعة الأولى) لمدة عشرة أيام تم قياس ضغط حجر العين قبل و بعد استخدام الأدوية المذكورة و كانت النتائج كالآتي : بالمقارنة مع المجموعة الأولى أحدث التايمولول انخفاضا ملحوظا في ضغط العين و كذلك فيتامين (سي). و عند استخدام التايمولول مع فيتامين (سي) انخفض ضغط حجر العين انخفاضا ملحوظا جدا و أكثر من استخدام أين من الأدوية على حدى و من هنا نستنتج أن فيتامين (سي) لديه أهمية ملحوظة في خفض ضغط العين.
Abstract EN
-d: Glaucoma is the second leading cause of blindness, after cataract.
Growing evidence suggested that the oxidative damage might be a relevant target for both glaucoma prevention and therapy.
Objective: The present study was undertaken to clarify the Intraocular pressure (IOP) lowering effect of vitamine C topical application.
Materials and methods: A total of 20 male of White New Zealand Rabbits were enrolled in the study.
Ocular hypertension was induced (by hyroxymethyl cellulose) in the right eye of all rabbits and the animals randomized into four groups, five rabbits each.
The animals then treated with eye drop of D.W (Group 1), timolol 0.5% (Group 2), vitamin C 0.5% (Group 3) and a combination of timolol 0.5% and vitamin C 0.5% (Group 4) three times daily for 10 days.
IOP was measured before and after drug treatment.
Results: Compared to group 1, Timolol 0.5% (15.66 ± 0.31 vs.
25.2 ± 0.29 mmHg,) and vitamin C 0.5% (17.57 ± 0.42 vs.
25.2 ± 0.29 mmHg) caused a significant (p < 0.05) decrease in IOP.
Further, a combination of Timolol 0.5% and vitamin C 0.5% produced highly significant (P < 0.01) fall in IOP.
Conclusion: We can concluded that vitamin C has a significant IOP lowering effect, possibly due to antioxidant properties
American Psychological Association (APA)
Kazim, Sinaa A.. 2010. Effect of vitamin c on intraocular pressure : an experimental study in rabbits. Kufa Medical Journal،Vol. 13, no. 2, pp.263-268.
https://search.emarefa.net/detail/BIM-379261
Modern Language Association (MLA)
Kazim, Sinaa A.. Effect of vitamin c on intraocular pressure : an experimental study in rabbits. Kufa Medical Journal Vol. 13, no. 2 (2010), pp.263-268.
https://search.emarefa.net/detail/BIM-379261
American Medical Association (AMA)
Kazim, Sinaa A.. Effect of vitamin c on intraocular pressure : an experimental study in rabbits. Kufa Medical Journal. 2010. Vol. 13, no. 2, pp.263-268.
https://search.emarefa.net/detail/BIM-379261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 267-268
Record ID
BIM-379261