Comparative effectiveness of antidiabetic drugs glibenclamide versus glibenclamide plus metformin on serum glucose concentration and serum c-peptide concentration in Iraqi diabetic type 2 patients

Abstract EN

Diabetes type2 is characterized by hyperglycemia, this hyperglycemia result from-dysfunction of beta-cells to secret adequate insulin that maintain serum glucose concentration.

C-peptide is an peptide with 31 amino acid this peptide play an important function in the synthesis of insulin, and now used as reliable indicator for insulin secretion in diabetes mellitus type 2.

We studied the effects of antidiabetic drug glibenclamide versus glibenclamide plus metformin on serum glucose concentration and serum c-peptide concentration in comparison with control group.

84 patients enrolled in this study and divided into 3 groups, in the first group patients treated with glibenclamide.

In the second group patients treated with glibenclamide plus metformin.

While the third group normal patients represent as control group.

Then we estimated the postprandial serum glucose concentration and serum c-peptide concentration for each patient in all groups.

Data collected and statistically analyzed.

We find that there is significant increase in serum glucose concentration in glibenclamide group and glibenclamide plus metformin when compared with control group ; also there is significant decrease in serum c- peptide concentration in glibenclamide group and glibenclamide plus metformin group when compared with control group.

These results strongly indicate that, there is a failure in effects of antidiabetic drugs used by Iraqi patients and there is dysfunction of beta-cells of pancreas to normalized serum glucose concentration.