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Cancer susceptibility and caspase 8 gene varient in local Iraqi population
Joint Authors
al-Shibli, Ifad Karim
Abd al-Razzaq, Muhammad Sabri
Muhsin, Muhammad Abbud
Source
Issue
Vol. 8, Issue 4 (31 Dec. 2011), pp.516-523, 8 p.
Publisher
University of Babylon College of Medicine
Publication Date
2011-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract AR
يعتبر سرطان الثدي من أكثر الأمراض السرطانية شيوعا.
يلعب جين الكاسبيز (CASP 8) دورا مهما في الكثير من مراحل نمو الثدي, تثبيط عمل هذا الجين قد يؤدي إلى الإصابة بسرطان الثدي, بينما يعتبر المتغاير الجيني D302H لجين الكاسبيز عاملا وقائيا ضد سرطان الثدي.
الهدف هو الكشف عن الدور الذي يلعبه المتغاير الجيني بالنسبة لقابلية الإصابة بسرطان الثدي.
تمت دراسة المتغاير الجيني لجين الكاسبيز عن طريق التحليل الوراثي لأربعة مجاميع شملت المرضى بسرطان الثدي, أقرباء من الدرجة الأولى, ناس أصحاء و مرضى مصابين بأورام حميدة في الثدي.
نتائج الدراسة أظهرت علاقة عكسية بين سرطان الثدي و وجود المتغاير الجيني, كذلك أظهرت النتائج إن وجود هذا المتغاير لدى النساء يؤخر ظهور السرطان.
Abstract EN
Background : Breast cancer is the most common cancer in women.
The incidence of breast cancer varies greatly around the world.
Apoptosis occurs naturally at several stages of breast development.
The gene caspase-8 (CASP8) plays a key role in the initiation of apoptosis.
Suppression of apoptosis is one of the major mechanisms underlying the origin and progression of cancer.
One variant in the CASP8 gene, D302H (rs1045485), has been confirmed to be associated with a reduced breast cancer risk.
Aim : To illustrate the role of the CASP8 gene variant with respect to breast cancer susceptibility.
According to our knowledge, there is no previous association study concerning CASP8 gene variant (D302H) and breast cancer has been conducted in Iraq.
So the frequency of this gene variant and its clinical impact on breast cancer was studied for the first time among Babylonian population.
Materials and methods : A genetic analysis was performed as single nucleotide polymorphism (SNP) to tag the D302H variant in four groups of Babylonian populations, including patients with breast cancer, healthy control people, first degree relatives, and patients with benign breast tumors.
Results : CASP8, D303H variant was shown to have a high degree of correlation with healthy control subjects in the present study in comparison with breast cancer patients.
The presence of CASP8, D302H polymorphism not only diminishes the high risk of breast cancer, but also delays the onset of breast cancer until late age.
Conclusions : The CASP8 D302H polymorphism decreases the breast cancer risk and delays the onset of the disease.
American Psychological Association (APA)
Abd al-Razzaq, Muhammad Sabri& Muhsin, Muhammad Abbud& al-Shibli, Ifad Karim. 2011. Cancer susceptibility and caspase 8 gene varient in local Iraqi population. Medical Journal of Babylon،Vol. 8, no. 4, pp.516-523.
https://search.emarefa.net/detail/BIM-379981
Modern Language Association (MLA)
Abd al-Razzaq, Muhammad Sabri…[et al.]. Cancer susceptibility and caspase 8 gene varient in local Iraqi population. Medical Journal of Babylon Vol. 8, no. 4 (2011), pp.516-523.
https://search.emarefa.net/detail/BIM-379981
American Medical Association (AMA)
Abd al-Razzaq, Muhammad Sabri& Muhsin, Muhammad Abbud& al-Shibli, Ifad Karim. Cancer susceptibility and caspase 8 gene varient in local Iraqi population. Medical Journal of Babylon. 2011. Vol. 8, no. 4, pp.516-523.
https://search.emarefa.net/detail/BIM-379981
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 523
Record ID
BIM-379981