Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute coronary syndrome patients
Joint Authors
Hamdan, Righab
Hajj, Fuad
Qadri, Zaynah
Kassab, Ruland
Salamah, Elie
Abu Jawdah, Simon
Azar, Rabih
Badawi, Georges
Source
Issue
Vol. 59, Issue 2 (30 Jun. 2011), pp.65-69, 5 p.
Publisher
Publication Date
2011-06-30
Country of Publication
Lebanon
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background and Aim : The effect of ezetimibe-statin combination on inflammatory markers in acute coronary syndrome is unknown.
The aim of our study is to evaluate the effect of this combination on the lipid profile, the CRP hs and the sCD40 ligand levels in acute coronary syndrome (ACS) patients.
Methods : This is a randomized, double-blind study including 93 patients admitted for ACS randomized in 2 groups, ezetimibe 10 mg + atorvastatin 10 mg vs atorvastatin 20 mg + placebo, for 12 weeks follow-up ; blood samples were collected for lipid profile, ALT, AST, CRP and sCD40L at baseline, 12 hours, 4 weeks, and 12 weeks.
Results : There was no significant difference in total cholesterol levels, HDL, LDL, CRP, but there was a significant decrease in sCD40L levels in the ezetimibe combination group, with less side effects in the combination group, mainly myalgia (p = 0.012).
Conclusion : Ezetimibe combination with low dose statin in patients in acute coronary syndrome could be a safe, potent therapy to reduce LDL level with anti-inflammatory effect.
American Psychological Association (APA)
Hamdan, Righab& Hajj, Fuad& Qadri, Zaynah& Kassab, Ruland& Salamah, Elie& Abu Jawdah, Simon…[et al.]. 2011. Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute coronary syndrome patients. Journal Médical Libanais،Vol. 59, no. 2, pp.65-69.
https://search.emarefa.net/detail/BIM-380230
Modern Language Association (MLA)
Abu Jawdah, Simon…[et al.]. Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute coronary syndrome patients. Journal Médical Libanais Vol. 59, no. 2 (2011), pp.65-69.
https://search.emarefa.net/detail/BIM-380230
American Medical Association (AMA)
Hamdan, Righab& Hajj, Fuad& Qadri, Zaynah& Kassab, Ruland& Salamah, Elie& Abu Jawdah, Simon…[et al.]. Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute coronary syndrome patients. Journal Médical Libanais. 2011. Vol. 59, no. 2, pp.65-69.
https://search.emarefa.net/detail/BIM-380230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 68-69
Record ID
BIM-380230