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CDX2 gene expression in acute lymphoblastic leukemia
Joint Authors
Mukhtar, Duha A.
Arnaoaut, Hana H.
Sami, Raniya M.
Khamis, Sahar A.
Shirin, Umar A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 26, Issue 2 (30 Jun. 2014), pp.55-59, 5 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
CDX genes are classically known as regulators of axial elongation during early embryogenesis.
An unsuspected role for CDX genes has been revealed during hematopoietic development.
The CDX gene family member CDX2 belongs to the most frequent aberrantly expressed protooncogenes in human acute leukemias and is highly leukemogenic in experimental models.
We used reversed transcriptase polymerase chain reaction (RT-PCR) to determine the expression level of CDX2 gene in 30 pediatric patients with acute lymphoblastic leukemia (ALL) at diagnosis and 30 healthy volunteers.
ALL patients were followed up to detect minimal residual disease (MRD) on days 15 and 42 of induction.
We found that CDX2 gene was expressed in 50 % of patients and not expressed in controls.
Associations between gene expression and different clinical and laboratory data of patients revealed no impact on different findings.
With follow up, we could not confirm that CDX2 expression had a prognostic significance.
American Psychological Association (APA)
Arnaoaut, Hana H.& Mukhtar, Duha A.& Sami, Raniya M.& Khamis, Sahar A.& Shirin, Umar A.. 2014. CDX2 gene expression in acute lymphoblastic leukemia. Journal of the Egyptian National Cancer Institute،Vol. 26, no. 2, pp.55-59.
https://search.emarefa.net/detail/BIM-380264
Modern Language Association (MLA)
Arnaoaut, Hana H.…[et al.]. CDX2 gene expression in acute lymphoblastic leukemia. Journal of the Egyptian National Cancer Institute Vol. 26, no. 2 (2014), pp.55-59.
https://search.emarefa.net/detail/BIM-380264
American Medical Association (AMA)
Arnaoaut, Hana H.& Mukhtar, Duha A.& Sami, Raniya M.& Khamis, Sahar A.& Shirin, Umar A.. CDX2 gene expression in acute lymphoblastic leukemia. Journal of the Egyptian National Cancer Institute. 2014. Vol. 26, no. 2, pp.55-59.
https://search.emarefa.net/detail/BIM-380264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 58-59
Record ID
BIM-380264