Assessment of leptin and resistin levels in non obese multiple myeloma patients and their relation with Ig level and disease stage

Abstract EN

Introduction : Multiple myeloma (MM) accounts for approximately 0.8 % of all cancer diagnoses and 0.9 % of cancer deaths.

Leptin receptors were expressed on CD34+ cells.

Resistin receptors were expressed on inflammatory cells and pro-inflammatory cytokines increase the expression of resistin on monocytes.

Aim of work : To assess the level of leptin and resistin in non-obese multiple myeloma patients and to study their relation with Ig level and disease stage.

Subjects & methods : 32 subjects were included ; 16 patients diagnosed with MM and 16 healthy individuals served as control.

All were subjected to history taking, clinical examination, routine laboratory investigations and leptin & resistin blood level.

Laboratory investigations were done for diagnosis and staging for MM patients.

Results : Leptin was significantly higher in MM patients compared with the control group, unlike resistin which showed no significant difference between the two groups.

A significant positive relation was found between IgG level & leptin.

Similarly, a significant difference in leptin level has been observed between stage I & stage II (higher in II).