Role of ZIP14 (SLC39A14) gene histidine rich regions in neural tube defects
Joint Authors
Akar, Najat
Akar, Ece
Torun, Didem
Yılmaz, Erkan
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 12, Issue 2 (31 Dec. 2011), pp.135-137, 3 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2011-12-31
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Topics
Abstract EN
Neural tube defects (NTDs) comprise a group of congenital malformations that includes spina bifida, anencephaly, meningomyelocele and encephalocele.
Reports have implicated zinc deficiency as one of the causative factors of NTDs.
Both environmental and genetic factors are involved in the etiology of NTDs.
Inadequate folate intake and nutritional deficiency are important environmental risk factors.
The aim of this study was to determine the relation of a zinc related gene ZRT and IRT like protein 14 (ZIP14) and neural tube defects in Turkish patients.
The case control study included seventy Turkish mothers who gave birth to NTD infants.
Two hundred and thirty-nine healthy controls were consecutively selected without any congenital defects or familial NTD history.
Following DNA extraction, PCR, SSCP and DNA sequencing analysis of exons of the ZIP14 gene were performed.
Our data revealed that no relation of neural tube defects and ZIP14 was detected in Turkish NTD patients.
Zinc deficiency have been reported as a risk factor for Turkish population and other possible zinc related gene defects may have importance.
American Psychological Association (APA)
Torun, Didem& Yılmaz, Erkan& Akar, Ece& Akar, Najat. 2011. Role of ZIP14 (SLC39A14) gene histidine rich regions in neural tube defects. The Egyptian Journal of Medical Human Genetics،Vol. 12, no. 2, pp.135-137.
https://search.emarefa.net/detail/BIM-380288
Modern Language Association (MLA)
Torun, Didem…[et al.]. Role of ZIP14 (SLC39A14) gene histidine rich regions in neural tube defects. The Egyptian Journal of Medical Human Genetics Vol. 12, no. 2 (2011), pp.135-137.
https://search.emarefa.net/detail/BIM-380288
American Medical Association (AMA)
Torun, Didem& Yılmaz, Erkan& Akar, Ece& Akar, Najat. Role of ZIP14 (SLC39A14) gene histidine rich regions in neural tube defects. The Egyptian Journal of Medical Human Genetics. 2011. Vol. 12, no. 2, pp.135-137.
https://search.emarefa.net/detail/BIM-380288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 137
Record ID
BIM-380288