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Null genetic risk of ACE gene polymorphisms with nephropathy in type 1 diabetes among Egyptian population
Joint Authors
Rashad, Muna
Tayyib, Muhammad T.
al-Hawwari, Nasir A.
Bogari, Neda
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 12, Issue 2 (31 Dec. 2011), pp.187-192, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2011-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Reported to date, strong evidence exists in multiple studies for genetic predisposing in the development of diabetic nephropathy, and no studies addressed this issue among Egyptian population.
The results of angiotensin converting enzyme gene (ACE) in the susceptibility to nephropathy in type 1 diabetes with nephropathy are conflicting.
We aim to identify the associations of two ACE gene polymorphisms (PstI, A > G substitution and a 287-bp insertion / deletion) with nephropathy in type 1 diabetes in Egyptian children / adolescents.
Our case-control study contained 140 diabetic individuals ; 80 diabetic with nephropathy as cases, and 60 diabetic subjects without nephropathy as control group.
Amplified DNA from peripheral leucocytes / buccal mucosa was genotyped for using polymerase chain reaction and enzymatic assay.
We found no significant differences in the distribution of ACE insertion / deletion and PstI genotypes or allele frequencies were observed between the examined groups.
Frequencies of PstI-indel haplotypes were similar in all of our study groups.
In both cases and control subjects, ACE activity and microalbuminuria were highest among D / D homozygotes and lowest in I / I homozygotes, while a dissimilar result was seen in PstI polymorphism.
Our findings in Egyptian population strongly conclude that there is no association between the ACE gene I / D and PstI polymorphisms with nephropathy in type 1 diabetes.
American Psychological Association (APA)
al-Hawwari, Nasir A.& Bogari, Neda& Rashad, Muna& Tayyib, Muhammad T.. 2011. Null genetic risk of ACE gene polymorphisms with nephropathy in type 1 diabetes among Egyptian population. The Egyptian Journal of Medical Human Genetics،Vol. 12, no. 2, pp.187-192.
https://search.emarefa.net/detail/BIM-380371
Modern Language Association (MLA)
al-Hawwari, Nasir A.…[et al.]. Null genetic risk of ACE gene polymorphisms with nephropathy in type 1 diabetes among Egyptian population. The Egyptian Journal of Medical Human Genetics Vol. 12, no. 2 (2011), pp.187-192.
https://search.emarefa.net/detail/BIM-380371
American Medical Association (AMA)
al-Hawwari, Nasir A.& Bogari, Neda& Rashad, Muna& Tayyib, Muhammad T.. Null genetic risk of ACE gene polymorphisms with nephropathy in type 1 diabetes among Egyptian population. The Egyptian Journal of Medical Human Genetics. 2011. Vol. 12, no. 2, pp.187-192.
https://search.emarefa.net/detail/BIM-380371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 191-192
Record ID
BIM-380371