Expression of syndecan-1 on neutrophils in patients with type 2 diabetes mellitus

Abstract EN

Background : Type 2 diabetes is a manifestation of an ongoing low-grade inflammation.

In diabetes, impairment of neutrophil adhesion to the endothelium and migration to the site of inflammation were detected, which were associated closely with adhesion molecules expressed on neu-trophils and endothelial cells.

Patients and Methods : To determine the expression of syndecan-1 on the neutrophils in diabetic patients, 80 patients with type 2 diabetes mellitus were recruited, in addition to 40 healthy individuals with no history of glucose metabolism disorders as control group.

Expression of syndecan-1 was determined using flow-cytometry, and the correlations between syndecan-1 expression and clinical characteristics were analyzed.

Results : The percentage of neutrophils expressing syndecan-1 was found to be higher in diabetic patients than among the healthy control individuals.

In addition, a statistically significant association was found between the percentage of syndecan-1 positive neutrophils and body mass index.

A multiple regression analysis found that body mass index is a significant predictor of neutrophils expressing syndecan-1 in type 2 diabetes mellitus patients.

Conclusion : Surface syndecan-1 on neutrophils is significantly enhanced in subjects with type 2 DM.

It is also positively correlated with BMI.