Assessment of the effects of antioxidants on the behavior of experimentally-induced parkinsonian model

Abstract EN

Background : Oxidative stress has been implicated in the neurodegenerative process of Parkinson's disease (PD).

Aim : this study was conducted to assess the effects of the antioxidants (vitamin C and vitamin E) to attenuate 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neuro-degenerative toxicity in mice.

Materials and Methods : Fifty-two male albino mice were divided into four groups.

All groups received MPTP intra-peritoneal injections (80 mg / kg, i.p.) divided into four doses within a single day.

The first group was pathological control group that received distilled water for 14 days and MPTP on day 7.

The second group received vitamin C (500 mg / kg / day, per oral) for 14 successive days, and received MPTP on day 7.

The third group received vitamin E (200 mg / kg / day, p.o.) for 14 successive days, and received MPTP on day 7.

The fourth group received a combination of vitamin C and vitamin E (250 mg / kg / day and 100 mg / kg / day, p.o.

respectively) and received MPTP on day 7.

Behavioral assessment was done on day 14 using open field and rotarod tests.

Water-soluble form of vitamin E was used and all vitamins were dissolved in distilled water prior to administration.

Results : Vitamin E-treated mice showed marked behavioral improvement when compared to control group, whereas vitamin C group showed the best motor performance and motor coordination, combination group did not show any augmented results.

Conclusion : Vitamin C and vitamin E were proven to be potential candidates to ameliorate behavioral MPTP toxicity in Parkinsonian mice.