Correlation of fractional excretion of magnesium with steroid responsiveness in children with nephrotic syndrome

Abstract EN

Steroid-resistant nephrotic syndrome (SRNS) patients are candidates for other alternative drug regimes, and the non-responsiveness to steroid is more common among glomerulonephritides other than minimal change disease.

Without performing biopsy and proper renal histology, progression of the disease cannot be assessed.

Fractional excretion of magnesium (FE Mg) has been found to correlate directly with various renal histologies.

The aim of this study is to evaluate the relationship of FE Mg in children with the histological pattern in SRNS.

In this prospective observational study, 40 children of nephrotic syndrome, both with the first episode as well as relapse, aged 1-12 years were included in the study.

Of them, 20 were steroid-responsive cases and 20 were steroid-resistant cases.

FE Mg was determined in all the patients and renal histology was performed in the steroid-resistant cases.

A correlation was found between FE Mg and renal histology.

Data were analyzed in SPSS program version-16.

Comparison of two groups was performed by the Fisher exact test and unpaired t test.

P-value less than 0.05 were considered to be significant.

The results of histopathology showed that the mean difference in FE Mg was significant (P < 0.001), as FE Mg was 7.0 ± 2.3 % in mesangiocapillary glomerulonephritis, 6.9 ± 1.3 % in focal segmental glomerulosclerosis, 4.7 ± 0.6 % in immunoglobulin M nephropathy, 4.5 ± 1.2 % in focal segmental proliferative glomerulonephritis, 4.4 ± 1.6 % in minimal change disease, 4.2 ± 0.4 % in diffuse mesangial proliferative glomerulonephritis and 3.8 ± 1.3 % in mesangial proliferative glomerulonephritis.

There was a statistically significant difference between FE Mg in steroid-resistant nephrotic syndrome (4.9 ± 1.9) and steroidresponsive syndrome (1.2 ± 0.3).

FE Mg is a simple, minimally invasive screening marker for SRNS, and is an early predictor of clinical outcome.

It can be considered as an initial investigation where biopsy cannot be performed or indications are not clear.