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Study of the effect of acrylamide oil purkinje cells of the cerebellum in albino rats
Joint Authors
al-Hayyani, Abd al-Munim A.
Hamdi, Raid Mahmud
Abd al-Rahim, Hisham N.
Source
Suez Canal University Medical Journal
Issue
Vol. 13, Issue 1 (31 Mar. 2010), pp.35-41, 7 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2010-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Objectives : Acrylamide has several toxic and carcinogenic effects.
The current research aimed to study the harmful effects of acrylamide on the structure of the Purkinje cells of the cerebellum in the albino rats, in an attempt to clarify its potential risk on the human health.
Methods : The study was performed at the Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia through the years 2008-2010.
A daily dose of 50 mg / kg body weight of acrylamide was administrated to adult male albino rats orally and intraperitoneally.
Their cerebella were obtained after two and four weeks of acrylamide administration, where serial sagittal sections were stained with H & E, and silver stains and examined microscopically.
Results : Rats treated with acrylamide 50 mg / kg body weight for two weeks showed mild degenerative changes in the form of diminished dendrites with less arborization of the Purkinje cells, while rats treated with the same dose for four weeks showed severe degenerative changes of Purkinje cells in the form of disintegrated dendrites and ill-defined arborization into the outer molecular layer.
Moreover, Purkinje cells bodies showed marked irregularity in cell boundary.
Silver staining showed deeply stained argyrophilic dendrites arborizing into the basal part of the outer molecular layer.
In addition, the Purkinje cells manifested a high affinity to silver so that they appeared brown in color, whether acrylamide was administered orally or intraperitoneally.
Conclusion : Exposure to acrylamide produced degenerative changes in the Purkinje cells of the cerebellum which were more prominent with the longer period of exposure.
American Psychological Association (APA)
al-Hayyani, Abd al-Munim A.& Hamdi, Raid Mahmud& Abd al-Rahim, Hisham N.. 2010. Study of the effect of acrylamide oil purkinje cells of the cerebellum in albino rats. Suez Canal University Medical Journal،Vol. 13, no. 1, pp.35-41.
https://search.emarefa.net/detail/BIM-380967
Modern Language Association (MLA)
al-Hayyani, Abd al-Munim A.…[et al.]. Study of the effect of acrylamide oil purkinje cells of the cerebellum in albino rats. Suez Canal University Medical Journal Vol. 13, no. 1 (Mar. 2010), pp.35-41.
https://search.emarefa.net/detail/BIM-380967
American Medical Association (AMA)
al-Hayyani, Abd al-Munim A.& Hamdi, Raid Mahmud& Abd al-Rahim, Hisham N.. Study of the effect of acrylamide oil purkinje cells of the cerebellum in albino rats. Suez Canal University Medical Journal. 2010. Vol. 13, no. 1, pp.35-41.
https://search.emarefa.net/detail/BIM-380967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 40-41
Record ID
BIM-380967