Anti-Saccharomyces cerevisiae antibodies and its relationship with radiological damage in ankylosing spondylitis
Joint Authors
al-Fiqqi, Inas Muhammad Abd al-Aziz
al-Shahawi, Iman al-Dasuqi
Fahmi, Dalia Samir
Samir, Hanan
Umran, Ala A. al-Muti
Najib, Ghadah Sanad
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 41, Issue 2 (30 Apr. 2014), pp.45-50, 6 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
-Aim The presence of anti-Saccharomyces cerevisiae antibodies (ASCA) is controversial in ankylosing spondylitis (AS).
In this study, we aimed to investigate the prevalence of ASCA in AS and its relationship with disease activity and radiological damage in patients attending Sharkia governorate hospitals. Patients and methods Thirty AS patients and 30 apparently healthy volunteers were included in the present study. All patients were questioned for Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis metrology Index and Bath Ankylosing Functional Index (BASFI).
Total Bath Ankylosing Spondylitis Radiology Index (BASRI-T) and ASCA levels were measured. Results ASCA IgA level was significantly higher in AS patients than in healthy controls (P < 0.001).
The ASCA-positive group, although not significant, tended to have higher BASFI scores.
ASCA IgA-positive patients had higher BASRI-T levels (P = 0.037).
In AS patients, significant positive correlation was found between ASCA IgA level and BASRI-T and BASFI (r = 0.19 and 0.31, respectively, P < 0.05).
Bath Ankylosing Spondylitis Disease Activity Index scores, BASFI and ASCA IgA positivity were significantly associated with increased BASRI-T (P= 0.01, 0.03 and 0.04, respectively).
The most significant risk factor for increased BASRI-T is ASCA IgA positivity (P < 0.001). Conclusion ASCA IgA was detected more frequently in AS patients than in healthy controls.
ASCA IgA could be considered a marker of severe radiological damage.
Further studies are recommended to investigate ASCA level versus radiological damage and intestinal involvement in AS
American Psychological Association (APA)
al-Shahawi, Iman al-Dasuqi& Fahmi, Dalia Samir& Najib, Ghadah Sanad& Samir, Hanan& Umran, Ala A. al-Muti& al-Fiqqi, Inas Muhammad Abd al-Aziz. 2014. Anti-Saccharomyces cerevisiae antibodies and its relationship with radiological damage in ankylosing spondylitis. Egyptian Rheumatology and Rehabilitation،Vol. 41, no. 2, pp.45-50.
https://search.emarefa.net/detail/BIM-381063
Modern Language Association (MLA)
al-Shahawi, Iman al-Dasuqi…[et al.]. Anti-Saccharomyces cerevisiae antibodies and its relationship with radiological damage in ankylosing spondylitis. Egyptian Rheumatology and Rehabilitation Vol. 41, no. 2 (Apr. 2014), pp.45-50.
https://search.emarefa.net/detail/BIM-381063
American Medical Association (AMA)
al-Shahawi, Iman al-Dasuqi& Fahmi, Dalia Samir& Najib, Ghadah Sanad& Samir, Hanan& Umran, Ala A. al-Muti& al-Fiqqi, Inas Muhammad Abd al-Aziz. Anti-Saccharomyces cerevisiae antibodies and its relationship with radiological damage in ankylosing spondylitis. Egyptian Rheumatology and Rehabilitation. 2014. Vol. 41, no. 2, pp.45-50.
https://search.emarefa.net/detail/BIM-381063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 50
Record ID
BIM-381063