Role of B-lymphocyte activating factor (BAFF) in the pathogenesis of systemic lupus erythematosus
Joint Authors
Salamah, Sharhan
Kamil, Nadiyah
Sabir, Nayyirah Z.
al-Tayyib, Muhammad
Maruf, Sharif
Kamil, Ahmad
Zamzam, Muna
Amir, Hana
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 40, Issue 2 (30 Jun. 2013), pp.96-100, 5 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2013-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background B-lymphocyte activating factor (BAFF) is a new member of the tumor necrosis factor family that promotes B-cell survival, acting as an antiapoptotic factor and thus contributing to the development of autoimmune disease.
Objectives The aim of the study was to investigate the role of BAFF in the pathogenesis of systemic lupus erythematosus (SLE) by correlating its serum levels to different clinicopathological indices of disease activity.
Methods This is a prospective study that was conducted on 20 female patients with SLE.
Ten healthy controls of matching age and sex were also included in this study.
All patients were subjected to full history taking and clinical examination upon presentation, and the following laboratory parameters were evaluated: complete blood picture, erythrocyte sedimentation rate, serum (creatinine, blood urea nitrogen), and complete urine analysis (anti nuclear antibody, anti-dsDNA, C3, C4 in serum).
Serum BAFF levels were measured by enzyme-linked immunosorbent assay in all patients.
Renal biopsy was performed whenever necessary.
Results Serum BAFF levels were significantly higher in patients with active SLE than in controls (Po0.05).
These levels also correlated positively with systemic lupus erythematosus disease activity index (SLEDAI) in a highly significant manner (Po0.001).
Correlating serum BAFF among patients with photosensitivity and symptoms of central nervous system affection proved to be highly significant (Po0.001).
In addition, within this study, serum BAFF levels correlated positively with ESR levels among patients and negatively with both C3 and C4 in a significant manner (Po0.05 and 0.001, respectively).
Conclusion Serum BAFF levels were significantly higher among patients with active SLE than among controls.
It correlated in a negative manner with both C3 and C4 – significantly with C3 and highly significantly with C4.
BAFF levels also correlated with SLEDAI in a highly significant manner, implicating B-cell immunoglobulin production and immune complex formation in the disease activity of lupus patients.
American Psychological Association (APA)
Salamah, Sharhan& Kamil, Nadiyah& Zamzam, Muna& Sabir, Nayyirah Z.& al-Tayyib, Muhammad& Maruf, Sharif…[et al.]. 2013. Role of B-lymphocyte activating factor (BAFF) in the pathogenesis of systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation،Vol. 40, no. 2, pp.96-100.
https://search.emarefa.net/detail/BIM-381206
Modern Language Association (MLA)
Salamah, Sharhan…[et al.]. Role of B-lymphocyte activating factor (BAFF) in the pathogenesis of systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation Vol. 40, no. 2 (Apr. / Jun. 2013), pp.96-100.
https://search.emarefa.net/detail/BIM-381206
American Medical Association (AMA)
Salamah, Sharhan& Kamil, Nadiyah& Zamzam, Muna& Sabir, Nayyirah Z.& al-Tayyib, Muhammad& Maruf, Sharif…[et al.]. Role of B-lymphocyte activating factor (BAFF) in the pathogenesis of systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation. 2013. Vol. 40, no. 2, pp.96-100.
https://search.emarefa.net/detail/BIM-381206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 100
Record ID
BIM-381206