In vitro study of the effects of some pediatric tonics and appetizers on the male rabbits intestinal (jejunal)‎ smooth muscle motility

Abstract EN

supplements are needed in very small amounts for growth and for maintaining good health.

They are especially useful for children who otherwise cannot or will not consume food that is a good vitamin and minerals source.

In the present study we try to investigate the effects of three different pediatric tonic syrups ( B-plex , Vitamin DR3R and ferosam) and pediatric appetizer cyproheptadine (periactin) ( Samara industry.

Iraq) (SDI), on mammalian intestinal smooth muscle motility, in an attempt to determine whether these medications can contribute to bowel dysfunction and pediatric constipation.

Segments of jejunum were isolated from rabbit's intestine and submerged in TyroidP’Ps solution which has the same composition of extracellular fluid of the rabbit, they were exposed to different volumes and concentrations of the four medications, and the responses were recorded by a lever which injects ink on a slowly moving drum.

Vitamin B-plex, vitamin DR3R and periactin pediatric syrups induced a dose-dependent inhibitions of spontaneous activity of the jejunum, they induced a significant decrease in the amplitude of jejunel contractions and relaxations(motility), while ferosam syrup shows a significant decrease in the amplitude of jejunal motility at 2ml(36mg) concentration only.