Synthesis and characterization of 1,3,4-oxadiazoles derivatives from 4-phenyl-semicarbazide
Other Title(s)
تحضير مشتقات جديدة ل 1،3،4-اوكسادايزول من مركب 4-فنيل سيماكاربازايد و تشخيصها
Joint Authors
Jasim, Ahmad Majid
Radi, Wisam Abd al-Hasan
Jabir, Hadi Abd al-Samad
Muhammad, Faiz Jumah
Source
Journal of Basrah Researches : Sciences
Issue
Vol. 39, Issue 3A (30 Sep. 2013)12 p.
Publisher
University of Basrah College of Education for Pure Sciences
Publication Date
2013-09-30
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract AR
في هذا البحث حضرت سلسلة من مشتقات جديدة لمركب -1(-2(-X فنيل) -5- (فنيل امينو) – 4،3،1- اوكسادايزول بوساطة تكاثف قاعدة شف مع حامض الخليك الثلجي، بينما حضرت قاعدة شف من تكاثف -4 فنيل سيماكاربازايد مع الالديهايدات الاروماتية المعوضة بموقع بارا.
حيث تمت متابعة التفاعلات باستخدام تقنية كروماتوغرافيا الطبقة الرقيقة و شخصت المركبات المحضرة بوساطة أطياف الرنين النووي المغناطيسي للبروتون، الأشعة تحت الحمراء، الأطياف المرئية وفوق البنفسجية و طيف الكتلة بالإضافة إلى استخدام الكيمياء الحاسوبية في حساب عزم ثنائي القطب، طاقات HOMO و LUMO و الطاقات الكلية للمركبات المحضرة.
Abstract EN
work, a series of novel 1-(2-(4-xphenyl)-5-(phenylamino)-1,3,4- oxadiazole-3(2H)-yl) ethanone (X=H,OH,Cl,NO2,N(CH3) (4a-e) were prepared from the condensation of Schiff base (3a-e) with acetic acid.
The azomethines were prepared from the corresponding 4-phenyl semi carbazide(1) with aryl aldehydes (2a-e).
This convenient method benefits from its broad applicability, ease and safety reagent handing, simple product isolation.
All the reaction was routinely monitored and purity was determined, on thin layer chromatography using coated aluminum plates and spots were visualized by exposing the dry plates in iodine vapours.
The structure elucidation of synthesized compound is based on the P1PHNMR, FTIR, U.V spectral data, mass spectroscopy , melting points and computational methods .
Our results indicate that the energy differences between the lowest unoccupied molecular orbit and the highest occupied molecular orbit are predominantly affected by the terminal groups of the Oxadiazoles compounds.
American Psychological Association (APA)
Jasim, Ahmad Majid& Radi, Wisam Abd al-Hasan& Jabir, Hadi Abd al-Samad& Muhammad, Faiz Jumah. 2013. Synthesis and characterization of 1,3,4-oxadiazoles derivatives from 4-phenyl-semicarbazide. Journal of Basrah Researches : Sciences،Vol. 39, no. 3A.
https://search.emarefa.net/detail/BIM-381573
Modern Language Association (MLA)
Jasim, Ahmad Majid…[et al.]. Synthesis and characterization of 1,3,4-oxadiazoles derivatives from 4-phenyl-semicarbazide. Journal of Basrah Researches : Sciences Vol. 39, no. 3A (2013).
https://search.emarefa.net/detail/BIM-381573
American Medical Association (AMA)
Jasim, Ahmad Majid& Radi, Wisam Abd al-Hasan& Jabir, Hadi Abd al-Samad& Muhammad, Faiz Jumah. Synthesis and characterization of 1,3,4-oxadiazoles derivatives from 4-phenyl-semicarbazide. Journal of Basrah Researches : Sciences. 2013. Vol. 39, no. 3A.
https://search.emarefa.net/detail/BIM-381573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-381573