Comparative evaluation of renal findings in beta-thalassemia Major and intermedia
Joint Authors
Derkhshan, Ali
Mahran, Karimi
Moghaddam, Abd al-Karim Ghadimi
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 19, Issue 2 (30 Apr. 2008), pp.206-209, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2008-04-30
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Thalassemia is a systematic disease in which the renal involvement has not yet been scrupulously studied.
In a cross-sectional study, the renal findings of 50 cases of thalassemia intermedia (group 1) were compared to 58 patients with thalassemia major (group 2).
Blood urea nitrogen, serum creatinine, uric acid, calcium, phosphorus, urinalysis, and ultrasonographical findings were evaluated.
Mean age was 18 ± 3.0 in group 1 and 17 ± 3.5 years in group 2.
The mean of serum ferritin levels was 871 ± 81.8 ng / ml in group 1 vs.
3503 ± 201 ng / ml in thalassemia major (p < 0.05).
Ninety-two percent of the patients in group 1 were on hydroxyurea at the time of evaluation.
Serum uric acid was significantly higher in group 1 than group 2 patients (5.74 ± 2.95 vs.
4.12 ± 0.9 mg / dl, p < 0.05).
Microscopic hematuria (red blood cell in high power field of urine microscopy > 5) was observed among 19 children (17.6%); 17 of them were in group 1.
In contrast, children with thalassemia major had significantly higher serum creatinine (0.89 ± 0.18 vs.
0.59 ± 0.37 mg / dl, p < 0.05) and blood urea nitrogen values (12.14 ± 5.58 vs.
13.85 ± 3.54 mg / dl, p < 0.05).
We conclude that significant renal involvement is not a frequent complication in children and young adults suffering from thalassemia.
Hyperuricemia and microscopic hematuria are more common in thalassemia intermedia than thalassemia major.
Microscopic hematuria in thalassemia intermedia might be related to either hypercalciuria or hyperuricosuria.
American Psychological Association (APA)
Derkhshan, Ali& Mahran, Karimi& Moghaddam, Abd al-Karim Ghadimi. 2008. Comparative evaluation of renal findings in beta-thalassemia Major and intermedia. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 2, pp.206-209.
https://search.emarefa.net/detail/BIM-38206
Modern Language Association (MLA)
Derkhshan, Ali…[et al.]. Comparative evaluation of renal findings in beta-thalassemia Major and intermedia. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 2 (Apr. 2008), pp.206-209.
https://search.emarefa.net/detail/BIM-38206
American Medical Association (AMA)
Derkhshan, Ali& Mahran, Karimi& Moghaddam, Abd al-Karim Ghadimi. Comparative evaluation of renal findings in beta-thalassemia Major and intermedia. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 2, pp.206-209.
https://search.emarefa.net/detail/BIM-38206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 208-209
Record ID
BIM-38206