Bleeding and thrombosis in a patients with secondry antiphospholipid syndrome
Joint Authors
Kaaroud, Hayet
Beji, Sumayyah
Bin Musa, Fatimah
Khidr, Adil
Bin Hamidah, Fathi
Bin Abd Allah, Tayyib
Guermazi, Sami
Izzi, Sami
al-Yunusi, Fathi
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 19, Issue 2 (30 Apr. 2008), pp.227-231, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2008-04-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
- Patients
- Arteries
- Diseases
- Protein deficiency
- Wounds and injuries
- Blood
- Anemia
- Complications(Medicine)
- Hemorrhage
- Coagulation
- Antiphospholipid syndrome
Abstract EN
Antiphospholipid antibodies have been associated with occurrence of arterial and venous thrombotic events and fetal loss, which together constitute the antiphospholipid syndrome (APS).
However, bleeding is rare in this syndrome.
We report a case of systemic lupus erythematosus (SLE) with APS complicated simultaneously by thrombotic and hemorrhagic events.
A 34-year-old woman was a known case of diffuse proliferative lupus nephritis associated with APS, on treatment with corticosteroids, cyclophosphamide and anticoagulants.
She presented in February 2004 with severe anemia, menorrhagia, gingival bleeding and acute loss of vision in the left eye.
Investigations revealed a hematoma in the psoas muscle with thrombosis of the inferior vena cava and occlusion of the retinal vein.
Blood tests revealed a strongly positive lupus anticoagulant, factor XI deficiency (35%) and decrease of free protein S (44%).
Factor XI inhibitor, anti-prothrombin, and anti-protein S antibodies were absent.
The patient was treated with corticosteroids and six pulses of cyclophosphamide, which resulted in a rapid disappearance of bleeding, reduction of hematoma and normalization of hematological abnormalities.
She was maintained on corticosteroids, azathioprine and anticoagulant agents were introduced.
After a follow-up of 28 months, there was no recurrence of bleeding, the thrombosis had resolved, and there was a decrease in the levels of circulating anticoagulant as well as anticardiolipin antibodies.
American Psychological Association (APA)
Beji, Sumayyah& Guermazi, Sami& Bin Musa, Fatimah& Bin Hamidah, Fathi& Izzi, Sami& Kaaroud, Hayet…[et al.]. 2008. Bleeding and thrombosis in a patients with secondry antiphospholipid syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-38226
Modern Language Association (MLA)
Kaaroud, Hayet…[et al.]. Bleeding and thrombosis in a patients with secondry antiphospholipid syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 2 (Apr. 2008), pp.227-231.
https://search.emarefa.net/detail/BIM-38226
American Medical Association (AMA)
Beji, Sumayyah& Guermazi, Sami& Bin Musa, Fatimah& Bin Hamidah, Fathi& Izzi, Sami& Kaaroud, Hayet…[et al.]. Bleeding and thrombosis in a patients with secondry antiphospholipid syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-38226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 230-231
Record ID
BIM-38226