Clinical observation of cytokines in patients with hepatitis B

Abstract EN

Thirty serum samples were collected from patients with chronic hepatitis B who were admitted to Hepatology and Gastroenterology Teaching Hospital in Baghdad during period from beginning of February / 2008 to the end of February / 2009, also serum samples were collected from 30 healthy HBs Ag carrier was discovered accidentally through attending blood bank for donation of blood and a total of 30 apparently healthy blood donors were included in the study served as a control group.

The concentrations of some cytokines Pg/ml (IFN-γ, GM-CSF, IL-1α, IL-6, IL-8 and IL-2 receptor) have been estimated in the sera of the studied groups and the results showed that mean levels of gamma-interferon, interleukin-1 alpha, interleukin-8 and interleukins-6 in sera of carriers group were (109.

6, 251.

6, 232.

9 and 166.

8 respectively) more than the level of these cytokines in sera of chronic HBV patients (75.1, 94.

7, 159.

6 and 110.

9 respectively) and healthy control (48.

4, 10.

1, 11.

3 and 15.

4 respectively), while the mean level of GM-CSF was elevated in sera of CHB patients (110.

8) than both of healthy control and carrier group (17.

3 and 41 .

2 respectively).

Finally the interleukin-2 receptor was represented with similar level in sera of chronic patients and carrier group ( 165.

6 and 167.9 respectively) with non significant difference, whereas all other statistical comparisons among the three main groups showed highly significant difference.