Association of serum fetuin-A and biochemical parameters in hemodialysis patients

Abstract EN

Fetuin-A, a hepatic glycoprotein present in the circulation, is a potential inhibitor for systemic calcification.

The main aim of this study was to evaluate the association between fetuin-A and other biochemical parameters as facilitator factors for developing atherosclerosis in hemodialysis (HD) patients.

This case-control study was conducted on 44 HD patients undergoing treatment in 2012.

Parathormone (i-PTH) and fetuin levels were performed by the enzyme-linked immunosorbent assay method, high-sensitivity C-reactive protein (hs-CRP) by chemiluminescence, low-density lipoprotein by direct enzymatic, calcium and albumin by colorimetric and phosphorous by ultraviolet (UV) methods.

Chi-square was used for evaluating the association between variables and t-test was used for comparing the mean of the quantitative variables for the two groups.

SPSS-16 software was used for data analysis and P-value less than 5 % was considered as significant.

Mean of serum fetuin level was 23.25 ± 4.90 ng / mL in HD patients and 32.92 ± 5.21 in the control group.

Median of hs-CRP was 2.45 mg / dL in the patients and 1.00 mg / dL in the control group and i-PTH was 74.3 pg / mL in the patients and 7.30 pg / mL in the control group.

The calcium-phosphorous product was 46.77 ± 14.22 mg / dL in the patient and 31.73 ± 6.48 mg / dL in the control group.

A reverse significant association was found between fetuin-A and hs-CRP in this study.

In this study, serum fetuin-A level in HD patients was lower than controls.

Therefore, a low level of fetuin-A seems to be associated with atherosclerosis, inflammation and malnutrition.