Effects of vitamin d and calcium supplementation on micro-architectural and densitometric changes of rat femur in a microgravity simulator model
Joint Authors
Kouhnavard, Marjan
Esfahani, Ensieh Nasli
Muntazari, Muhammad
Hashemian, Sayyid Jafar
Mehrazma, Mitra
Larijani, Baqir
Asl, Amir Nizami
Khoshvaghti, Amir
Falsafi, Ammar
Lalehfar, Komeil
Malekpour, Keyvan
Vosugh, Mihran
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 6 (30 Jun. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-06-30
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Revealing data on the role of vitamin D and calcium supplementation in bone health has led some to suggest that vitamin D and calcium treatment could also play a role in protecting bone against microgravity-induced mineral loss.
Objectives: The aim of the present study was to investigate the effects of vitamin D and calcium administration on microscopic and densitometric changes of rat femur in a Microgravity Simulator Model.
Materials and Methods: After designing a Microgravity Simulator Model, 14 rats were placed in the cages as follows: seven rats as osteoporosis group and seven rats received oral supplement of calcium/vitamin D as the treatment group.
Animals were sacrificed after eight weeks and then both femurs were removed.
Bone mineral density was measured for one femur from each animal, and morphologic studies were evaluated for the contralateral femur.
Results: Bone mineral density of the whole femur in the treatment group was significantly higher than the osteoporosis group (0.168 ± 0.005 vs.
0.153 ± 0.006, P = 0.003).
Also, bone mineral content of the whole femur was significantly higher in treatment group (0.415 ± 0.016 vs.
0.372 ± 0.019, P = 0.003).
However, resorption eroded surface percentage was higher in the osteoporosis group (18.86 ± 3.71% vs.
9.71 ± 1.61%, P = 0.002).
Conclusions: According to the results of this study, vitamin D and calcium administration might have protective effects against microgravity-induced mineral loss in a Rat Microgravity Simulator Model
American Psychological Association (APA)
Kouhnavard, Marjan& Esfahani, Ensieh Nasli& Muntazari, Muhammad& Hashemian, Sayyid Jafar& Mehrazma, Mitra& Larijani, Baqir…[et al.]. 2014. Effects of vitamin d and calcium supplementation on micro-architectural and densitometric changes of rat femur in a microgravity simulator model. Iranian Red Crescent Medical Journal،Vol. 16, no. 6, pp.1-6.
https://search.emarefa.net/detail/BIM-383513
Modern Language Association (MLA)
Kouhnavard, Marjan…[et al.]. Effects of vitamin d and calcium supplementation on micro-architectural and densitometric changes of rat femur in a microgravity simulator model. Iranian Red Crescent Medical Journal Vol. 16, no. 6 (Jun. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-383513
American Medical Association (AMA)
Kouhnavard, Marjan& Esfahani, Ensieh Nasli& Muntazari, Muhammad& Hashemian, Sayyid Jafar& Mehrazma, Mitra& Larijani, Baqir…[et al.]. Effects of vitamin d and calcium supplementation on micro-architectural and densitometric changes of rat femur in a microgravity simulator model. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 6, pp.1-6.
https://search.emarefa.net/detail/BIM-383513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-383513