Effects of recombinant human erythropoietin on revascularization of full thickness skin grafts in rat
Joint Authors
Fatimi, Muhammad Javad
Imami, Abul Hasan
Ghiasi, Sina
Jafari, Sayyid Murtada Sayyid
Muhammadi, Ali Akbar
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 5 (31 May. 2014), pp.1-4, 4 p.
Publisher
Publication Date
2014-05-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : Autologous skin graft is frequently used in the field of plastic, and reconstructive surgery.
The engraftment is dependent upon revascularization and angiogenesis, which can be regulated by different factors.
In addition to its hematopoietic effects, erythropoietin is shown to positively affect the wound healing process.
Objectives : We studied effects of human erythropoietin on revascularization of full thickness skin grafts in rat.
Materials and Methods : Forty adult Albino male rats were selected for this study.
Full thickness skin graft was performed for them, and the effects of systemic, and localized administration of erythropoietin on vascularization of the graft area were evaluated in four groups as following : inverse group underwent full thickness skin graft ; in normal saline group normal saline was injected under the fascia of grafted area for seven days ; systemic EPO group received systemic erythropoietin for seven days after the surgery ; and in graft EPO group, erythropoietin was injected under the fascia of grafted area after full thickness skin grafting for seven days.
Results : Forty adult Albino male rats (n = 40), with weights ranging from 356 to 469 g (mean 391.5 ± 29.6 g) were included.
The vascular densities of central margins were significantly different between inverse group and graft EPO groups (P value = 0.01), and vascular density of central margins of normal saline group and graft EPO groups were significantly different too (P value = 0.04).
Conclusions : EPO can stimulate angiogenesis which has an important role in wound healing.
So, local administration of EPO seems to be beneficial in engraftment.
American Psychological Association (APA)
Fatimi, Muhammad Javad& Imami, Abul Hasan& Ghiasi, Sina& Jafari, Sayyid Murtada Sayyid& Muhammadi, Ali Akbar. 2014. Effects of recombinant human erythropoietin on revascularization of full thickness skin grafts in rat. Iranian Red Crescent Medical Journal،Vol. 16, no. 5, pp.1-4.
https://search.emarefa.net/detail/BIM-385384
Modern Language Association (MLA)
Fatimi, Muhammad Javad…[et al.]. Effects of recombinant human erythropoietin on revascularization of full thickness skin grafts in rat. Iranian Red Crescent Medical Journal Vol. 16, no. 5 (May. 2014), pp.1-4.
https://search.emarefa.net/detail/BIM-385384
American Medical Association (AMA)
Fatimi, Muhammad Javad& Imami, Abul Hasan& Ghiasi, Sina& Jafari, Sayyid Murtada Sayyid& Muhammadi, Ali Akbar. Effects of recombinant human erythropoietin on revascularization of full thickness skin grafts in rat. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 5, pp.1-4.
https://search.emarefa.net/detail/BIM-385384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3-4
Record ID
BIM-385384