Immune status study of dentistry student and children naturally infected with measles virus for detection of primary and secondary immune failures

Abstract EN

This study was carried out on 52 subject of Babylon dentistry student and children who were naturally infected with measles virus and laboratory confirmed as measles during 2009 by detection of specific anti-measles IgM .They were tested for IgG avidity to estimate their immune status and to distinguish between primary measles infection and reinfection due to secondary vaccine failure.

The study reflected that all unvaccinated subjects (19.2 %) showed a primary immune response whereas secondary immune responses were detected in (46.09 %).

Of 34 subjects sourly vaccinated (42.9 %) of them reflected a primary immune response, whereas (57.1 %) of them reflected secondary immune response ,thereby indicating a secondary vaccine failure that was seen at very high proportion in subjects >11 years old, so that revaccination of 11 years old children is recommended for reactivation of their immune status to restrict secondary reinfection.