The additional effect of granisteron over propofol and sevoflurane on prophylaxis of vomiting after pediatric adenotonsillectomy

Abstract EN

Introduction : Postoperative vomiting (POV) after adenotonsillectomy in children is a common problem with an incidence as high as 40–80 %.

Only few studies in the literature compared the effect of different anesthetic techniques concerning postoperative vomiting in children.

Objectives : To compare the effect of granisteron over propofol and sevoflurane in prevention of POV after adenotonsillectomy in children.

Patients and methods : This cohort, double blind study included 80 children with age between 4 and 12 years, undergoing tonsillectomy ± adenoidectomy, they were divided into 4 equal groups, in groups (I, II) the induction and maintenance of anesthesia were done by propofol, granisteron was given 5 min before extubation to group II.

In groups (III, IV) induction and maintenance were done by sevoflurane, granisteron was given 5 min before extubation to group IV.

Results : The incidence of vomiting 24 h after surgery was 30 % among all patients, with lower incidence in groups I and II than groups III and IV.

Groups II and IV had the lowest incidence of postoperative vomiting Conclusions : On performing adenotonsillectomy in children, the incidence of postoperative vomiting is lower with (i.v.

anesthetics) propofol than (volatile anesthetics) sevoflurane.

Use of granisteron significantly reduces the incidence of postoperative vomiting in children undergoing this procedure.