Xanthine oxidase activity as an index of lipid peroxidation in sera of patient with mayocardial infraction in Erbil City population

Abstract EN

Mayocardial infarction (MI) remains a leading cause of morbidity and mortality world wide.

MI occurs when myocardial ischaemia exceeds a critical threshold and overwhelms mayocardial cellular repair mechanisms designed to normal operating functions and homostatus.

Activity of xanthine oxidase (XO), MDA and vit-C concentrations were determined in sera of 100 patients with MI.

Their mean±SD age was (57.05 ± 1.25) year.

The same parameters were determined in sera of 100 apparently healthy matched subjects as a control group.

The mean ±SE of XO, MDA, and vit-C in patients with MI was 0.031 ± 0.016 unit / mg protein, 1.28 ± 0.053 μ mol / L, 0.520 ± 0.137 mg /dl respectively while the mean ± SE of control group was 0.012 ± 0.006 unit / mg protein, 0.819±0.019 μ mol, and 0.648 ± 0.302 mg / dl respectively.

There were significant differences in the mean value of XO and MDA in patient with MI compared to control group (P < 0.001).

However the mean value of vit-C showed no significant differences in both groups.