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Familial colorectal cancer
Author
Source
Issue
Vol. 10, Issue 1 (31 Mar. 2004), pp.55-59, 5 p.
Publisher
University of Basrah College of Medicine
Publication Date
2004-03-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Most colorectal cancers regardless of etiology are believed to arise from adenomatous polyps.
Both environmental and genetic factors are important in colorectal carcinogenesis.
Twenty five percent of patients with colorectal cancer have relevant family history.
We tried to verify the spectrum of manifestations of hereditary non polyyposis colorectal cancer HNPCC and what practical preventive measures could be applied.
In related families, 4 generations were studied via interviewing.
Seventeen patients fulfilled the Amsterdam’s criteria for the diagnosis of HNPCC (Lynch II), with a mean age of 59.11 11.75, 10 patients were females and 7 were males.
All were not smokers.
The pedigree we mapped for these families showed an autosomal dominant inheritance.
HNPCC is heterogeneous syndrome.
Although has certain gene defect.
We should always think of HNPCC in presence of positive family history of colorectal cancer or other malignancy specially those affecting young age groups.
Regular colonoscopy and aspirin prophylaxis are important preventive measures.
American Psychological Association (APA)
Hashim, Ali Rahim. 2004. Familial colorectal cancer. Basrah Journal of Surgery،Vol. 10, no. 1, pp.55-59.
https://search.emarefa.net/detail/BIM-385621
Modern Language Association (MLA)
Hashim, Ali Rahim. Familial colorectal cancer. Basrah Journal of Surgery Vol. 10, no. 1 (Mar. 2004), pp.55-59.
https://search.emarefa.net/detail/BIM-385621
American Medical Association (AMA)
Hashim, Ali Rahim. Familial colorectal cancer. Basrah Journal of Surgery. 2004. Vol. 10, no. 1, pp.55-59.
https://search.emarefa.net/detail/BIM-385621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 59
Record ID
BIM-385621