Some biochemical changes in patients with bladder cancer

Abstract EN

Objective : To estimate some biochemical changes in patients with bladder cancer.

Patients : One hundred patients admitted to Al-Hilla General Teaching Hospital and to the Radiation Oncology and Nuclear Medicine Hospital in Baghdad, and 30 healthy controls were included in this study which lasted from February to June 2011.

The patients included 72 males and 28 females, their ages ranged from 41-84 years, with a mean age of 63 years.

Those patients were divided into male and female subgroups.

As well as, the healthy controls were matched in age and sex with them.

Results : This study demonstrated that the majority of patients (42 %) fall in the age group 60-70 years ; the male to female ratio was 2.57 : 1 with 72 % of patients being males and 28 % being females.

Smoking was the most important risk factor for developing bladder cancer accounting for 55 % of patients followed by occupational exposure (42 %) and environmental exposure (15 %).

Further ; 80 % of patients were found to have stage II and III disease accounting for 50 % and 30 %, respectively, and 95 % of patients presented with grade II and III disease, being 64 % and 31 %, respectively.

The most common type of bladder cancer was transitional cell carcinoma accounting for 95 % of patients.

The total serum protein, albumin and globulin were found to have a significant decrement; whereas C-reactive protein was significantly increased in both male and female patients compared to the control group.

Serum iron and calcium were significantly decreased in both male and female patients in comparison with the control group.

Serum zinc was significantly decreased while serum copper showed a significant increment in both male and female patients compared to the control group.

Conclusion: The changes of all previously mentioned markers in bladder cancer patients might be potentially important findings as a biochemical tools for the disease.