Leukocytes count and neutrophillymphocytes ratio in predicting in-hospital outcome after acute myocardial infarction

Abstract EN

After an acute myocardial infarction, Leukocytosis and increase neutrophils to lymphocytes ratio (NLR) may be associated with increased risk of inhospital heart failure, and death.

Objectives : To evaluate the role of total WBC count and NLR as an in-hospital predictor for adverse events (death and heart failure) for the patients presented with acute MI.

Methods : A total of 98 patients who had no history of heart failure presented with acute myocardial infarction were studied in Marjan Teaching Hospital along their hospitalization period (i.e.

for one week) by measuring total WBC count and NLR for each patient ; Echocardiography and chest x-rays were done for patients to determine whom developed heart failure, any death occured during hospitalization had been also documented.

Results : Patients were divided into 3 groups according to a cut lines (mean & 80 centile), (1st centile = 48 patients, 2nd centile = 29 patients, 3rd centile = 19 patients).

Most patients with high baseline WBC count were associated with the development of heart failure (p value < 0.05) and increase in-hospital mortality (p value < 0.05).

Regarding the NLR it showed that higher ratio was associated with the development of heart failure (P value < 0.05), and with increasing mortality.

WBC count and NLR were independent predictors of in-hospital death after application of the Binary Regression Analysis.

Conclusion : 1- WBC count and NLR are predictors of adverse in-hospital outcome (heart failure and death) after acute myocardial infarction. 2- Both WBC count and differential ratio (NLR) are independently acting as predictors for in-hospital mortality.