Hydro-methanolic extract of cornus mas L. and blood glucose, lipid profile and hematological parameters of male rats
Joint Authors
Abd Allahi, Bita
Abbasi, Mahran Mesgari
Milani, Parvin Zakeri
Nourdadgar, Ashraf Sadat
Khojasteh, Sayyid Mahdi Banan
Najati, Vahid
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 5 (31 May. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-05-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Cornus mas L, an olive-shaped red-colored single-seeded fruit, is used in traditional medicine in different parts of Europe and Asia.
Objectives : In the present study, 40 male Wistar rats were randomly divided into five groups, and the effects of 21 days of intraperitoneally (IP) administration of 50, 200 and 400 mg / kg body weight of C.
mas hydro-methanolic extract on the rats hematological and biochemical parameters were investigated.
The experimental study was carried out in Tabriz, Iran.
Materials and Methods : The hematology and biochemical tests were performed by the Technicon H1 Hematology Analyzer and enzymatic methods, respectively.
Results : The results indicated that all doses of the extract caused significant (P < 0.05) decreases in the hemoglobin distribution width (HDW) (2.3 ± 0.2 vs.
2.5 ± 0.2, P = 0.049) and platelet distribution width (PDW) (56.5 ± 1.8 vs.
63.9 ± 3.6, P = 0.001) of the treated groups vs.
control group, whereas only high doses caused significant elevation in the mean corpuscular hemoglobin concentration (MCHC) (30.3 ± 0.8 vs.
28.6 ± 0.6, P = 0.047), mean platelet volume (MPV) (5.0 ± 0.6 vs.
4.1 ± 0.3, P = 0.002), total platelet mass (PCT) (0.33 ± 0.07 vs.
0.26 ± 0.01, P = 0.050), and significant decrease in the red cell distribution width (RDW) (13.8 ± 0.4 vs.
14.7 ± 1.3, P = 0.048) of the treated groups vs.
control group.
Conclusions : Decreasing effect of the extract on platelet activity might classify it as an alternative for antiplatelet therapy in cardiovascular diseases (CVD).
The results of this study suggested that further investigations with higher doses of C.
mas fruit extract are necessary to obtain significant protective and nonprotective changes in hematological and biochemical parameters.
American Psychological Association (APA)
Abd Allahi, Bita& Abbasi, Mahran Mesgari& Milani, Parvin Zakeri& Nourdadgar, Ashraf Sadat& Khojasteh, Sayyid Mahdi Banan& Najati, Vahid. 2014. Hydro-methanolic extract of cornus mas L. and blood glucose, lipid profile and hematological parameters of male rats. Iranian Red Crescent Medical Journal،Vol. 16, no. 5, pp.1-6.
https://search.emarefa.net/detail/BIM-385722
Modern Language Association (MLA)
Abd Allahi, Bita…[et al.]. Hydro-methanolic extract of cornus mas L. and blood glucose, lipid profile and hematological parameters of male rats. Iranian Red Crescent Medical Journal Vol. 16, no. 5 (May. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-385722
American Medical Association (AMA)
Abd Allahi, Bita& Abbasi, Mahran Mesgari& Milani, Parvin Zakeri& Nourdadgar, Ashraf Sadat& Khojasteh, Sayyid Mahdi Banan& Najati, Vahid. Hydro-methanolic extract of cornus mas L. and blood glucose, lipid profile and hematological parameters of male rats. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 5, pp.1-6.
https://search.emarefa.net/detail/BIM-385722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6
Record ID
BIM-385722