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Clinical presentation and biochemical evaluation of bone secondaries
Joint Authors
Hamdan, Thamir Ahmad
Hashim, Falih W.
al-Naama, Lamya M.
Source
Issue
Vol. 10, Issue 2 (30 Sep. 2004)11 p.
Publisher
University of Basrah College of Medicine
Publication Date
2004-09-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
The skeleton is one of the commonest sites for metastasis.
Bone secondaries account for more than one third of the malignant disease of bone.
Seventy-six patients with bone secondaries were admitted in the orthopaedic department of Basrah Teaching Hospital from February 2000 to June 2002, age range 14-86 years ; 34 were males and 42 were females.
The dominant sites of bone metastases were spine, 60 patients (79 %) and pelvis, 16 patients (21 %).
The common primary sites were breast, 19 patients (25 %) and lung, 11 patients (14.4 %) ; 9 patients (11.2 %) had undetected primary site.
Most secondaries (90 %) were osteolytic in type and the most common histopathological type was adenocarcinoma, 47 patients (63 %).
In 63 patients (83 %), pain was the dominant presenting feature.
Late presentation was a major problem ; it ranges between 4-8 months.
Another problem was lack of clinical awareness in the early stage of the illness.
Serum and urinary biochemical markers of bone metabolism were significantly high in patients with bone secondaries than control group, no difference whether the metastasis was single or multiple and whichever the primary site or histopathological subtype.
Special interest with urinary hydroxyproline, it was significantly elevated in patients with bone secondaries, some of them had negative radiography.
Prognosis was poor with short life expectancy.
American Psychological Association (APA)
Hamdan, Thamir Ahmad& al-Naama, Lamya M.& Hashim, Falih W.. 2004. Clinical presentation and biochemical evaluation of bone secondaries. Basrah Journal of Surgery،Vol. 10, no. 2.
https://search.emarefa.net/detail/BIM-385766
Modern Language Association (MLA)
Hamdan, Thamir Ahmad…[et al.]. Clinical presentation and biochemical evaluation of bone secondaries. Basrah Journal of Surgery Vol. 10, no. 2 (Sep. 2004).
https://search.emarefa.net/detail/BIM-385766
American Medical Association (AMA)
Hamdan, Thamir Ahmad& al-Naama, Lamya M.& Hashim, Falih W.. Clinical presentation and biochemical evaluation of bone secondaries. Basrah Journal of Surgery. 2004. Vol. 10, no. 2.
https://search.emarefa.net/detail/BIM-385766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-385766