Contribution of inflammation to vascular diseases in chronic kidney diseases patients
Joint Authors
al-Sulayman, Muhammad H.
Stenvinkel, Peter
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 19, Issue 3 (30 Jun. 2008), pp.329-345, 17 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2008-06-30
Country of Publication
Saudi Arabia
No. of Pages
17
Main Subjects
Topics
- Patients
- Cardiovascular system
- Kidneys
- Diseases
- Chronic diseases
- Anti-inflammatories
- Inflammation
- Complications(Medicine)
- Kidney failure
Abstract EN
Chronic kidney disease (CKD) is characterized by an exceptionally high mortality rate, much of which results from cardiovascular disease (CVD).
Chronic low-grade inflammation, as evidenced by increased levels of pro-inflammatory cytokines and C-reactive protein (CRP), is a common feature of CKD and may cause atherosclerotic CVD through various pathogenetic mechanisms.
Evidence suggests that persistent inflammation may also be a risk factor for progression of CKD, which may result in a vicious inflammation-driven circle.
The causes of inflammation in CKD are multifactorial.
The influence of various comorbidities may contribute to inflammation in the setting of progressive loss of renal function.
Available data suggest that pro-inflammatory cytokines also play a central role in the genesis of the metabolic syndrome.
There is a lack of epidemiological data on the prevalence and consequences of inflammation in relation to protein-energy wasting (PEW) and CVD in CKD patients from developing countries.
The 'westernization' of nutritional intakes and changes of life style besides the high prevalence of chronic infections in developing countries are possible additive contributors to a high prevalence of inflammation, PEW and CVD among CKD patients.
Also, genetic differences may affect inflammatory responses and nutritional status and, thus, the susceptibility to CVD in different regions.
American Psychological Association (APA)
al-Sulayman, Muhammad H.& Stenvinkel, Peter. 2008. Contribution of inflammation to vascular diseases in chronic kidney diseases patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 3, pp.329-345.
https://search.emarefa.net/detail/BIM-38581
Modern Language Association (MLA)
al-Sulayman, Muhammad H.& Stenvinkel, Peter. Contribution of inflammation to vascular diseases in chronic kidney diseases patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 3 (Dec. 2008), pp.329-345.
https://search.emarefa.net/detail/BIM-38581
American Medical Association (AMA)
al-Sulayman, Muhammad H.& Stenvinkel, Peter. Contribution of inflammation to vascular diseases in chronic kidney diseases patients. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 3, pp.329-345.
https://search.emarefa.net/detail/BIM-38581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 337-345
Record ID
BIM-38581