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Normal references levels of serum Cystatin C in Saudi Arabia
Joint Authors
al-Wakil, Jamal S.
Hammad, Durdana
Mimun, Nawaz A. H.
Tarif, Numan
Mutawalli, Ahmad Hassan
Chaudhary, Abd al-Rauf
Isnani, Arthur C.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 19, Issue 3 (30 Jun. 2008), pp.361-370, 10 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2008-06-30
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
- Chemistry
- Patients
- Penal functions
- Medical examinations
- Laboratory diagnosis
- Saudi Arabia
- Blood
- Clinical chemistry
- Cystatin C
Abstract EN
This is the first report from Saudi Arabia studying the normal reference intervals in adult Saudi subjects and evaluating serum cystatin C as a prospective marker for the assessment of the glomerular filtration rate (GFR).
Three hundred healthy adult Saudi subjects including 156 males (52%) and 144 females (48%), with a mean age of 31.21 ± 9.82 years were prospectively studied to establish normal reference ranges for cystatin C.
A total of 68.34% of the study patients were in the age-group of 21-40 years.
The mean serum cystatin C in the 300 healthy subjects was 0.751 ± 0.11 mg / L (0.50 - 1.09), increasing gradually with age: it was 0.738 ± 0.11 mg / L (0.51 - 1.09) in the agegroup 21 - 30 years and 0.807 ± 0.12 (0.51 - 1.09) among subjects who were > 50 years of age.
The mean serum cystatin C in females (0.778 ± 0.118 mg / L) was significantly hig-her than in males (0.726 ± 0.095 mg / L) (p < 0.0001).
The serum cystatin C level was within the defined reference range of 0.53 - 0.95 mg / L in 95% of the subjects with a mean value of 0.74 ± 0.097 mg / L, and was falling within the 95% confidence interval of 0.73865 - 0.7637 mg / L, and with 98.84% area under the curve (AUC).
All the other renal function markers (urea, serum crea-tinine, calculated GFR, BMI) among the studied subjects were within the normal reference ranges for adult Saudi population.
The serum cystatin C level had a significant correlation with the body mass index (BMI) (r = 0.155; p = 0.007) and a correlation with serum creatinine as well (r = 0.009; p = 0.873).
It showed a negative correlation with calculated GFR as per Cockroft-Gault equation (r = - 0.101; p = 0.083).
American Psychological Association (APA)
al-Wakil, Jamal S.& Mimun, Nawaz A. H.& Chaudhary, Abd al-Rauf& Mutawalli, Ahmad Hassan& Tarif, Numan& Isnani, Arthur C.…[et al.]. 2008. Normal references levels of serum Cystatin C in Saudi Arabia. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 3, pp.361-370.
https://search.emarefa.net/detail/BIM-38590
Modern Language Association (MLA)
al-Wakil, Jamal S.…[et al.]. Normal references levels of serum Cystatin C in Saudi Arabia. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 3 (Dec. 2008), pp.361-370.
https://search.emarefa.net/detail/BIM-38590
American Medical Association (AMA)
al-Wakil, Jamal S.& Mimun, Nawaz A. H.& Chaudhary, Abd al-Rauf& Mutawalli, Ahmad Hassan& Tarif, Numan& Isnani, Arthur C.…[et al.]. Normal references levels of serum Cystatin C in Saudi Arabia. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 3, pp.361-370.
https://search.emarefa.net/detail/BIM-38590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 369-370
Record ID
BIM-38590