Correlation of new vitamin C derivatives with alanine amino transferase and aspartate amino transferase activities

Abstract EN

Background : Liver enzymes are commonly found in liver cells and when the liver is damaged, liver cells release their enzymes into the blood stream.

Vitamin C is a low-weight molecular antioxidant and is effective in the aqueous phase in protecting different parts of cells against free radicals.

An enzyme inhibitor is a molecule, which binds to enzymes and affect their activity.

Objective : This study was carried out to investigate the effect of new vitamin C derivative on serum liver enzymes.

Research design and methods : Eight samples were used.

Liver enzymes activity measured with and without vitamin C derivative.

Results : The result showed a reduced activity of aspartate aminotransferase (AST), and alanine transferase (ALT) after addition of vitamin C derivative.

Conclusion : It is concluded that the decrease in ALT, and AST activities were due to noncompetitive inhibition of enzymes by vitamin C derivative.